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Sildenafil Citrate – Miracle Drug to Treat Erectile Dysfunction in Men A Glimpse on Sildenafil Citrate • Sildenafil Citrate was the first effective oral medicine approved for the treatment of erectile dysfunction in men by Food and Drug Administration (FDA) in the year 1998. • It was a blockbuster medicine. • Within six months of its approval by FDA, millions of prescriptions were written for Sildenafil Citrate • It is a potent cGMP-specific phosphodiesterase type 5 (PDE-5) inhibitor. • It is a prescription based medicine and non-habit forming medicine. • Generic versions of Sildenafil Citrate at cheaper prices is also available nowadays Mechanism of Action • Eleven types of phosphodiesterase (PDE) are present in body • PDE-type 5 is predominantly present inside penile region. • Sildenafil citrate prevents the degradation of cGMP by inhibiting PDE type 5 enzyme. • Sexual stimulation results in release of Nitric Oxide(NO). • The release of nitric oxide stimulates the synthesis of cGMP which causes relaxation of smooth muscles inside penis and dilation of the blood vessels present inside the penis. • The dilated blood vessels increase the amount of blood flowing into the penis which produces a firm and strong erection. Onset of action and Duration of effect • The action of this medicine is observed within half an hour to 2 hours after taking the medicine. • The onset of action varies from person to person. • The effect of this medicine lasts for duration of 4 hours. Dosing Instructions • The most commonly prescribed dose of Sildenafil citrate is100mg once in a day. • This medicine needs to be taken 45 minutes to 60 minutes before having sexual intercourse. • This medicine is to be taken with a glass of water. • Take this medicine as directed by physician. • The medicine can be consumed with or without food. • Do not split, crush or chew the tablet. Precautions and Warnings • Tell your doctor your complete medical history before starting this medicine. • The patients with a history of allergy to Sildenafil Citrate or any other PDE-5 inhibitor should not take this medicine. • This medicine is contraindicated with nitrates andblood pressure lowering medicines. • Avoid any outdoor activity while taking sildenafil citrate as it may induce drowsiness. • Avoid intake ofalcohol, grapefruit juice and fatty foodwhile on treatment with Sildenafil citrate. • Use of Sildenafil citrate should be avoided in pregnant women, nursing mothers and men below 18 years of age. Common Side effects • Headache • Vision disturbances • Back pain and muscle pain • Flushing • Nasal Congestion • Nausea • Dizziness • Skin rash Buy Sildenafil Online Website : https://www.medexpressrx.com/sildenafil-citrate.aspx Email Us : Call us At : [email protected] +1-800-808-3375 Thank You !!!