Sildenafil Citrate – Miracle Drug to
Treat Erectile Dysfunction in Men
A Glimpse on Sildenafil Citrate
• Sildenafil Citrate was the first effective oral medicine approved for the treatment
of erectile dysfunction in men by Food and Drug Administration (FDA) in the year
1998.
• It was a blockbuster medicine.
• Within six months of its approval by FDA, millions of prescriptions were written for
Sildenafil Citrate
• It is a potent cGMP-specific phosphodiesterase type 5 (PDE-5) inhibitor.
• It is a prescription based medicine and non-habit forming medicine.
• Generic versions of Sildenafil Citrate at cheaper prices is also available nowadays
Mechanism of Action
• Eleven types of phosphodiesterase (PDE) are present in body
• PDE-type 5 is predominantly present inside penile region.
• Sildenafil citrate prevents the degradation of cGMP by inhibiting PDE type 5 enzyme.
• Sexual stimulation results in release of Nitric Oxide(NO).
• The release of nitric oxide stimulates the synthesis of cGMP which causes relaxation of
smooth muscles inside penis and dilation of the blood vessels present inside the penis.
• The dilated blood vessels increase the amount of blood flowing into the penis which
produces a firm and strong erection.
Onset of action and Duration of effect
• The action of this medicine is observed within half an hour to 2 hours after taking
the medicine.
• The onset of action varies from person to person.
• The effect of this medicine lasts for duration of 4 hours.
Dosing Instructions
• The most commonly prescribed dose of Sildenafil citrate is100mg once in a day.
• This medicine needs to be taken 45 minutes to 60 minutes before having sexual
intercourse.
• This medicine is to be taken with a glass of water.
• Take this medicine as directed by physician.
• The medicine can be consumed with or without food.
• Do not split, crush or chew the tablet.
Precautions and Warnings
• Tell your doctor your complete medical history before starting this medicine.
• The patients with a history of allergy to Sildenafil Citrate or any other PDE-5
inhibitor should not take this medicine.
• This medicine is contraindicated with nitrates andblood pressure lowering
medicines.
• Avoid any outdoor activity while taking sildenafil citrate as it may induce
drowsiness.
• Avoid intake ofalcohol, grapefruit juice and fatty foodwhile on treatment with
Sildenafil citrate.
• Use of Sildenafil citrate should be avoided in pregnant women, nursing mothers
and men below 18 years of age.
Common Side effects
• Headache
• Vision disturbances
• Back pain and muscle pain
• Flushing
• Nasal Congestion
• Nausea
• Dizziness
• Skin rash
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