DOPA_PRMs_Examples_3..

Report
Pre-Tx T1+C
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
IOIS: 3401
Pre-Tx 18F-FDOPA PET
Post-Tx 18F-FDOPA PET
Difference Post-Pre Tx 18F-FDOPA PET
RESPONDER
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
Change in 18F-FDOPA Signal
- Decrease
+ Increase
Pre-Tx T1+C
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
IOIS: 3401
Difference Post-Pre Tx 18F-FDOPA PET
Change in 18F-FDOPA Signal
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
- Decrease
+ Increase
Pre-Tx T1+C
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
IOIS: 2383
Pre-Tx 18F-FDOPA PET
Post-Tx 18F-FDOPA PET
Difference Post-Pre Tx 18F-FDOPA PET
NON-RESPONDER
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
Change in 18F-FDOPA Signal
- Decrease
+ Increase
Pre-Tx T1+C
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
IOIS: 2383
Difference Post-Pre Tx 18F-FDOPA PET
NON-RESPONDER
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
Change in 18F-FDOPA Signal
- Decrease
+ Increase
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
Pre-Tx DOPA Tumor Volume = 117.5 mL
RESPONDER
DOPA
PRM
Change in 18F-FDOPA Signal
% Decreasing DOPA Uptake = 93.0%
% Increasing DOPA Uptake = 7.0 %
Pre-Tx DOPA Tumor Volume = 18.3 mL
NON-RESPONDER
DOPA
PRM
% Decreasing DOPA Uptake 72.8%
% Increasing DOPA Uptake = 27.2 %
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
- Decrease
+ Increase
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
RESPONDER
All Changes
> 25% Change
> 50% Change
% Decreasing DOPA Uptake = 93.0%
% Decreasing > 25% change = 47.9%
% Decreasing > 50% change = 18.2%
% Increasing DOPA Uptake = 7.0 %
% Increasing > 25% change = 0.9%
% Increasing > 50% change = 0.0%
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
% Change in 18F-FDOPA Signal
- 100%
+ 100%
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
NON-RESPONDER
All Changes
> 25% Change
> 50% Change
% Decreasing DOPA Uptake = 72.8%
% Decreasing > 25% change = 31.9%
% Decreasing > 50% change = 2.7%
% Increasing DOPA Uptake = 27.2 %
% Increasing > 25% change = 3.2%
% Increasing > 50% change = 0.05%
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
% Change in 18F-FDOPA Signal
- 100%
+ 100%
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
% Decreasing DOPA
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
% Increasing DOPA
POSITRON EMISSION TOMOGRAPHY PARAMETRIC RESPONSE MAP (PET-PRM)
RESPONDER
VOLUME OF DECREASING DOPA UPTAKE = 175.5 mL
VOLUME OF INCREASING DOPA UPTAKE = 0.8 mL
NON-RESPONDER
VOLUME OF DECREASING DOPA UPTAKE = 7.4 mL
VOLUME OF INCREASING DOPA UPTAKE = 1.2 mL
Change in 18F-FDOPA Signal
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
- Decrease
+ Increase
XXXX
18F-FDOPA PET Parametric Response Maps (PET PRMs)
Baseline: 3/10/09
10/20/09
3/30/10
10/12/10
2/15/11
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
Change in PET Signal
-5000
+ 5000
XXXX
18F-FDOPA PET Parametric Response Maps (PET PRMs)
Baseline: 3/10/09
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
Pre-Tx T1+C
MALIGNANT MARKER MAPS (18F-FLT and 18F-FDOPA )
IOIS: 3401
Pre-Tx 18F-FDOPA PET
Pre-Tx 18F-FLT PET
Combined 18F-FLT and 18F-FDOPA
FLT
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011
DOPA
FLT+DOPA
MALIGNANT MARKER MAPS (18F-FDOPA + CBV + ADC )
Benjamin M. Ellingson, Ph.D., Dept. of Radiological Sciences, David Geffen School of Medicine at UCLA, 2011

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