Fragala - LIFE at UCF - University of Central Florida

Report
University of Central Florida
Preventing Sarcopenia
Muscular Adaptations
to Strength Training
ExeRcise in Seniors
Maren Fragala, PhD, CSCS*D
Institute of Exercise Physiology & Wellness
“Sarcopenia”
• Greek words sarx (flesh) and penia (loss)
= the process of age-related loss of skeletal
muscle mass and size
Reason for creating term:
• “…no decline with age is as dramatic or
potentially more significant than the decline
in lean body mass.”
• “…if this phenomenon were to be taken
seriously, we had to give it a name.”
Irwin H. Rosenberg, MD (1989)
2
Rosenberg IH. Sarcopenia: origins and clinical relevance. J Nutr. 1997 May;127(5 Suppl):990S-991S.
Prevalence of Sarcopenia
asm/m2 < 2 SD
New Mexico Elder Health Survey
(1993-1995)
Sarcopenia
14%
No
Sarcopenia
86%
14% in those
aged 65–69 y
3
No
Sarcopenia
50%
Sarcopenia
50%
>50% in those
80 y or older
Baumgartner et al. Epidemiology of sarcopenia among the elderly in New
Mexico. Am. J. Epidemiol. 1998. 147(8): 755–763.
Difficulty with daily tasks
• Physical disability
was ~ 4X greater in
sarcopenic older
men and women
than in older
persons with a
normal muscle mass
4
No
Sarcopenia
50%
Sarcopenia
50%
Baumgartner et al. Epidemiology of sarcopenia among the elderly in New
Mexico. Am. J. Epidemiol. 1998. 147(8): 755–763.
No diagnosis
• NO accepted clinical
criteria for diagnosis
• NO pharmaceutical
interventions to treat
symptoms
Our Objective:
• To determine if a novel blood biomarker
relates to muscle adaptations
5
Implications:
• Treatment of the
debilitating condition
The study…
Muscular Adaptations to Strength Training
Exercise in Seniors (MASTERS)
MASTERS Study Video
6
Skeletal Muscle
7
Blood test
8
Results: (Part 2)
Blood Test
Exercise
2000
Control
5.5
P3NP (ng/mL)
5.0
4.5
4.0
3.5
(baseline =4.53 + 1.80 to post = 4.88 + 1.86)
Lean Body Mass Change (g)
1500
1000
500
0
0
5
10
15
-500
-1000
-1500
(r = 0.422, p = 0.045)
-2000
3.0
pre
9
post
-2500
Baseline P3NP (ng/mL)
Fragala MS, et al. Biomarkers of Muscle Quality: N-Terminal Propeptide of Type III Procollagen and
C-terminal Agrin Fragment Responses to Resistance Exercise Training in Older Adults. Journal of
Cachexia, Sarcopenia and Muscle. 2014 (In Press).
Special Thanks
The motivated and dedicated participants!
Graduate Students!
10

similar documents