Bcl-2

Report
Bcl-2 and its Role
in Cancer
Mitochondria in the Cell
http://micro.magnet.fsu.edu/cells/mitochondria/images/mitochondriafigure1.jpg
Cytochrome C’s Dual Functionality
Protein that carries
electrons in electron
transport chain
between
mitochondrial
membranes
BUT released into
cytosol, triggers
apoptosis
http://upload.wikimedia.org/wikipedia/commons/thumb/b/ba/Cytochrome_C.png/250pxCytochrome_C.png
Bcl-2 family – apoptosis regulators
http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lympho
ma_htmlcourse/page3
Apoptosis
Pathway
http://www.reading.ac.uk/nitricoxide/intro/apoptosis/mito2.jpg
Stress signal (DNA damage, heat
shock)
Pro-apoptotic members activated
Cytochrome c release via MOMP
Cytochrome c complexes with ATP
and Apaf-1 (enzyme)
Caspase-9 activated, then forms
apoptosome with previous complex
Caspase cascade to apoptosis
Bcl-2 Knockout
Mice
• Viable, but smaller
• Half die by 6 weeks
• Smaller kidneys
• Skeletal
development
• Immune failure
http://openi.nlm.nih.gov/detailedresult.php?img=2132464_JCB.amling5g&req=4
NonHodgkin
Lymphoma
https://encryptedtbn3.gstatic.com/images?q=tbn:ANd9GcTkoz4iPsXeDUTi1dbV1wzIQsD8sDB7HqkRJaxih9U4
UWe9Cusd-A
Bcl-2 Translocations Found in
Cancer
http://www.sciencedirect.com/science/article/pii/S0167488903001885
Overexpression of Bcl-2 on the
Outer Membrane of Mitochondria
http://www.cancer.gov/cancertopics/understandingcancer/targetedtherapies/lymphoma_
htmlcourse/page3
Inhibiting Bcl-2
http://www.cancer.gov/images/targetedtherapies/lymphoma/m4s3c_1.jpg
Potential Therapeutic Undergoing
Clinical Trials
http://www.cancer.gov/PublishedContent/Images/images/targetedtherapies/lymphoma/
m4s3c_3.jpg
Sources
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2
132464/
• http://www.scq.ubc.ca/apoptosis/
• http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3
220196/pdf/iep_79.pdf
• http://www.cancer.gov/cancertopics/understandi
ngcancer/targetedtherapies/lymphoma_htmlcou
rse
• http://www.sciencedirect.com/science/article/pii
/S0167488903001885

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