WT1 and Wilms* Tumor

WT1 and Wilms’ Tumor
Sarah DeHart
DNA-binding transcription factor
Protein carries 4 C-terminal zinc fingers
36 different isoforms based on splicing
Specific isoforms can have different functions
WT1 Expression in Development
WT1 Pathway
WT1 Role in EMT/MET
WT1 inheritance patters
What’s wrong here?
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