SciLifeLab projects 2014

Report
Vision
To be an internationally leading center that develops,
uses and provides access to advanced technologies for
molecular biosciences with focus on health and
environment.
Organization
Board
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Professor Göran Sandberg, Government appointed Chair, Executive Director,
Knut and Alice Wallenberg Foundation
Margareta Olsson Birgersson, Government appointed Industry representative,
Medical Director, Roche Sweden
Professor Sophia Hober, Dean of Faculty, KTH Royal Institute of Technology
Stellan Sandler, Pro Vice-Chancellor, Uppsala University
Professor Hans Adolfsson, Pro Vice-Chancellor, Stockholm University
Professor Hans-Gustaf Ljunggren, Dean of Research, Karolinska Institutet
Professor Maria Anvret, Senior Advisor, University of Gothenburg
Professor Gunilla Westergren-Thorsson, Dean of Faculty of Medicine, Lund
University
Professor Karl-Eric Magnusson, Linköping University
National Reference Committee
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Karl-Eric Magnusson (Linköping University)
Anders Malmström (Lund University)
Göran Larsson (University of Gothenburg)
Jens Nielsen (Chalmers University of Technology)
Johan Schnürer (Swedish University of Agricultural Sciences)
Bernt-Eric Uhlin (Umeå University)
Neus Visa (Stockholm University)
Henrik Grönberg (Karolinska Institutet)
Stefan Ståhl (KTH Royal Institute of Technology)
Bengt Westermark (Uppsala University)
SciLifeLab Scientific Advisory Board
• Bertil Andersson, Chair (Nanyang Technological University, Singapore)
• Sören Brunak (Technical University of Denmark, Denmark)
• Jan Ellenberg (EMBL Heidelberg, Germany)
• Yoshihide Hayashizaki (RIKEN Omics Science Center, Japan)
• Sirpa Jalkanen (University of Turku, Finland)
• Janet Jansson (Pacific Northwest National Laboratory, Richland, WA, USA)
• Jonathan Knowles (University of Basel, FIMM University of Helsinki,
Switzerland)
• Svante Pääbo (Max Planck Institute for Evolutionary Anthropology,
Germany)
• Aviv Regev (Broad Institute, MIT, USA)
• Janet Thornton (EMBL-EBI, UK)
Scientific directors
Mathias Uhlén
Kerstin Lindblad-Toh
Executive
management
Karin DahlmanWright
Gunnar von Heijne
Karin Forsberg
Nilsson
Stefan Bertilsson
Joakim Lundeberg
Helene Andersson
Svahn
Mats Nilsson
Ulf Landergen
Strategic
management
Faculty
Site management Stockholm
Site management Uppsala
Funding
Platforms and facilities
Process for selection
Budget
SciLifeLab projects 2014
3000
2632
2500
2235
Projects
2000
1500
941
1000
529
500
292
0
2010
2011
2012
Year
2013
2014
SciLifeLab projects 2014
Regional facilities
of national interest
745
Affinity
Proteomics
167
Bioimaging
20
Bioinformatics
782
Structural Biology
55
National
Genomics Functional
Infrastructure genomics
26
728
Chemical Biology
Consortium
Sweden
37
Clinical
Drug Discovery Diagnostics
and Development
43
29
SciLifeLab projects 2014
Umeå University
4%
Swedish
University of
Agricultural
Sciences
8%
Chalmers
University of
Technology
1%
University of
Gothenburg
3%
Swedish
Umeå
University of University
Agricultural
1%
Sciences
3%
Mid Sweden
University,
Södertörn
University, Örebro
University
<1%
Uppsala University
33%
Lund
University
1%
University of
Gothenburg
4%
Linköping
University,
Linnaeus
University,
Södertörn
University
1%
KTH Royal
Institute of
Technology
2%
Lund University
7%
Uppsala
University
46%
Linnaeus
University
1%
Linköping
University
3%
Stockholm
University
6%
KTH Royal
Institute of
Technology
7%
Karolinska
institutet
27%
National facilities
Karolinska
institutet
40%
Stockholm
University
2%
Regional facilities of national interest
SciLifeLab projects 2014
Industry and other
Swedish organizations
8%
International
2%
Academic users
90%
Distribution of projects by user group
SciLifeLab projects 2014
International
23%
Healthcare
25%
Industry
21%
Public agency
28%
Institute
3%
Distribution of projects from organizations
outside Swedish academia
SciLifeLab projects 2014
Unnamed field
31%
Health
49%
Other
2%
Basic research
5%
Environment
13%
Distribution of projects within field of science
SciLifeLab publications 2010-2014
600
514
500
31
458
Publications
22
60
400
321
48
68
82
7
32
300
221
25 ≥ JIP
9 ≤ JIP <25
48
6 ≤ JIP <9
9
30
200
JIP <6
367
29
294
100
94
7
10
12
234
153
65
0
2010
2011
2012
Year
2013
2014
Examples of high impact papers 2014
• Skoglund P, Malmstrom H, Omrak A, et al. 2014. Genomic Diversity and
Admixture Differs for Stone-Age Scandinavian Foragers and Farmers.
Science 344:747-750.
• Wallberg A, Han F, Wellhagen G, et al. 2014. A worldwide survey of
genome sequence variation provides insight into the evolutionary history
of the honeybee Apis mellifera. Nat Genet 2014;46:1081-8.
• Gad H, Koolmeister T, Jemth AS, et al. 2014. MTH1 inhibition eradicates
cancer by preventing sanitation of the dNTP pool. Nature 508:215-221.
Examples of high impact papers 2014
• Huber KVM, Salah E, Radic B, et al. 2014. Stereospecific targeting of MTH1
by (S)-crizotinib as an anticancer strategy. Nature 508:222-227
• Hammar P, Wallden M, Fange D, et al. 2014. Direct measurement of
transcription factor dissociation excludes a simple operator occupancy
model for gene regulation. Nature Genet 46:405• Caspeta L, Chen Y, Ghiaci P, et al. 2014. Biofuels. Altered sterol
composition renders yeast thermotolerant. Science 346:75-78
• Branca RMM, Orre LM, Johansson HJ, et al. 2014. HiRIEF LC-MSMS enables
deep proteome coverage and unbiased proteogenomics. Nat Methods
11:59-62.
Examples of high impact papers 2014
• Carneiro M, Rubin CJ, Di Palma F, et al. 2014. Rabbit genome analysis
reveals a polygenic basis for phenotypic change during domestication.
Science 2014;345:1074-9.
• -Brawand D, Wagner CE, Li YI, et al. 2014. The genomic substrate for
adaptive radiation in African cichlid fish. Nature 513:375• Dumanski J, Rasi, Lönn M, C, et al. 2014. Smoking is associated with
mosaic loss of chromosome Y. Science Vol. 347 no. 6217 pp. 81-83
SciLifeLab Fellows
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Magda Bienko from Massachusetts Institute of Technology
Jens Carlsson from Stockholm University
Simon Elsässer from University of Cambridge
Sebastian Deindl from Harvard University
Marc Friedländer from Centre for Genomic Regulation (CRG)
Paul Hudson from U.C Berkeley and KTH Royal Institute of Technology
Tanja Slotte from Uppsala University
Ilaria Testa from Max Planck Institute for Biophysical Chemistry
Strategic recruitments
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Manfred Grabherr from Broad Institute of Harvard and MIT
Carolina Wählby from Broad Institute of Harvard and MIT
Thomas Helleday from the University of Oxford/Stockholm University
Lukas Käll from Stockholm University
Sven Nelander from the University of Gothenburg
Carsten Daub from RIKEN
Thijs Ettema from Uppsala University
Erik Ingelsson from Karolinska Institutet
Mats Nilsson from Uppsala University
Per Arvidsson from AstraZeneca
Petter Brodin from Stanford University
Simone Immler from Uppsala University
Sophie Sanchez from Uppsala University
Cecilia Williams from University of Houston
SciLifeLab courses 2014
Workshop Bioinformatics
15
Workshop
25
Course Bioinformatics
44
Web-based course
1
Seminar Bioinformatics
3
Summer School
1
Seminar
41
Course
61
Total number of courses, seminars and workshops (number of events focusing on
bioinformatics grouped separately) that SciLifeLab has organized or highly
contributed to during 2014.
SciLifeLab courses 2014
Linköping University
20
Linnaeus University
2
Lund University
5 Länssjukhuset
Ryhov
AstraZeneca
1
1
National Board of
Forensic Medicine
1
Swedish Museum of
Natural History
4
Sahlgrenska
University Hospital
3
Swedish University
of Agricultural
Sciences
37
National Veterinary
Institute
2
Södertörn University
KTH
3
Umeå University
16
10
Karolinska Institutet
University of
32
Gothebnurg
2
Chalmers University
of Technology
2
Uppsala University
73
Stockholm
University
16
Participants in bioinformatics courses organized by SciLifeLab during 2014 - University affiliation
SciLifeLab courses 2014
Doctoral
79
Advanced
91
Basic
21
Level of education - courses, seminars and workshops that SciLifeLab has
organized or highly contributed to.
AIMday & healthcare
Year
Activity
Description and Results
2011
AIMday Cancer
28 workshops with 80 researchers and 21 company
representatives
2012
AIMday Diabetes
16 workshops with 70 researchers and 16 company
representatives. Resulted in 3 new research collaborations
2012
AIMday Cancer
26 workshops with 70 researchers and 28 company
representatives. One major spin off was the discussion
group on real-time register data (see below). Plus a
number of other smaller projects
2013
AIMday Diagnostics &
Biomarkers
23 workshops with 60 researchers and 24 company
representatives. At least two collaborations started.
2013
AIMday CNS Disorders
25 workshops with 59 researchers and 31 company
representatives.
2014
AIMday Cancer
Combined program with workshops on specific indications
as well as companies’ questions.40 academic researchers
and 12 company representatives. One collaboration has
started.
2014
AIMday Bioimaging
In Dec 2014
Outreach activities
• SciLifeLab Day
• Workshops
• Roadshows
Science & SciLifeLab Prize for young scientists
• global prize, established in 2013 by the scientific
journal Science and SciLifeLab
• awarded annually
to four young
scientists for
outstanding life
science research
for which he/she
was awarded a
doctoral degree in
the previous
Keystone Symposia on Molecular and Cellular Biology
• nonprofit organization
headquartered in USA
• 50-60 peer-reviewed
conferences in life
science world wide
every year
• SciLifeLab supports the organization of Keystone
Symposia in Stockholm
SciLifeLab – in the media
Science 328,805 (14 May 2010)
Nature 484, 171 (12 April, 2012)
Nature 502, 711-712
(31 October, 2013)
Science 336, 136 (13 April, 2012)
Issues & opportunities
Future remarks

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