The Role of the Ratio of Omega 6s to Omega 3s in Optimal Health The superior Marine Lipid Complex Essential Fatty Acids Required by the human body to manufacture and repair cell membranes Protect cells from inflammation Cannot be made in sufficient quantities therefore must be obtained from food Two types: Alpha-linolenic acid (Omega-3) Linoleic acid (Omega-6) Omega 6 and 3 Fish /Marine Oils Walnuts Omega 3/Omega 6 Imbalance Changes in food manufacturing processes have resulted in high amounts of Omega 6 Hydrogenated oils High-fructose corn syrup Genetically engineered corn and soy products Omega 3/Omega 6 Ratio Western Diet 1 Recommended Diet Omega 3 1 Omega 6 20 1 Inflammatory Pathways Omega3 Foods Walnuts Flaxseed Green Vegetables Linoleic Acid (LA) Pro-Inflammatory Omega6 Foods Corn Oil Soy Oil Safflower Oil Arachidonic Acid (AA) Alpha- Linolenic- Acid (ALA) EPA/DHA Fish/ Animal Sources COX1 COX2 5LOX PGG2 5-HPETE PGH2 Leucotriene A4 Anti-Inflammatory Prostaglandins (PG2) Prostaglandins (PG3) Thromboxane (TXA) Thromboxane (LTB5) Leucotriene B4 Leucotriene (B5) Cysteinyl Leucotrienes Omega 3/6 Imbalance Leads to Inflammation Bodies natural biological protective response of tissue to harmful stimuli Pathogens Cell damage Irritants Chronic inflammation characterized by simultaneous tissue healing and destruction Inflammation is the Basis of Most Degenerative Disease Asthma Alzheimer’s Cardiovascular Disease Metabolic Syndrome Osteoarthritis Rheumatoid Arthritis Inflammatory Bowel Disease Dysmenorrhea Delayed Muscle Soreness And many more…. Effects of Reducing Omega-6:Omega-3 Ratio In secondary prevention of cardiovascular disease, a ratio of 4:1 Omega-6 to Omega-3 fatty acids associated with 70% decrease in total mortality DeLongeril M, er al. Mediterranean alpha-linoleic acid-rich diet in secondary prevention of coronary heart disease. Lancet 1994; 343: 1454-9. Effects of Reducing Omega-6:Omega-3 Ratio Lowering the ratio to 5:1, resulted in alterations in 5-series leukotriene excretion in an asthmatics in ameliorating methacholine-induced respiratory distress Broughton KS, et al. Reduced asthma symptoms with omega-3 fatty acid ingestion are related to 5series leukotriene production. Am J Clin Nutr 1997; 65: 1011-17. Effects of Reducing Omega-6:Omega-3 Ratio Lowering the Omega-6: Omega-3 ratio by 4:1 by using 4gm of omega-3 fatty acids produced inhibition of production of IL-1β and TNFα associated with rheumatoid arthritis James MJ, Cleland LG. Dietary omega-3 fatty acids and therapy for rheumatoid arthritis. Semin Arthritis Rheum 1997; 27: 85-97. The OMAPREM Difference With 30 years of Clinical Studies, OMAPREM is proven to be a Powerful, Effective Cox-2 and 5Lox inhibitor. OMAPREM In addition to EPA and DHA, OMAPREM contains over 30 fatty acids that contribute to its anti inflammatory benefits. As well as 4 novel compounds* *Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel (Perna canaliculus)(PCSO-524™) S. McPhee a , L .D. Hodges a , P.F.A. Wright b , P.M. Wynne c , N. Kalafatis a , D.W. Harney a, T.A. Macrides a,⁎ *Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus A.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎ COX2 Inflammation 5LOX Inflammation / Swelling OMAPREM Novel Compounds A structurally related family of ω-3 PUFAs was identified in the most bioactive fractions, which included: C18:4 C19:4 C20:4 C21:5 The novel compounds may be biologically significant as AI agents, as a result of their in vitro inhibition of lipoxygenase products of the AA pathway. *Novel anti-inflammatory ω-3 PUFAs from the New Zealand green-lipped mussel, Perna canaliculus A.P. Treschow a, L.D. Hodges a, P.F.A. Wright b, P.M. Wynne c, N. Kalafatis a, T.A. Macrides a,⁎ OMAPREM The Superior Choice Purity Potency Efficacy Science Partner Program Fish Oil Source May contain man made pollutants if taken from natural sources Heavy Metals PCB’s Pesticides Radiation Farm raised fish have lower amounts of Omega 3s and higher amounts of Omega 6s due to corn/grain diet Bio-magnification http://www.hsph.harvard.edu/nutritionsource/fish/ Fish Oil Source Fish, like salmon, consume smaller fish or krill that consume the plankton. Fish also can absorb industrial contaminates (like mercury) by eating smaller fish. The farther up the food chain the higher the level of contaminates http://www.hsph.harvard.edu/nutritionsource/fish/ Krill- Sustainability National Geographic Magazine has warned about the 80 percent drop in krill populations over the last few decades This drop could potentially harming already depleted whale and other marine mammal populations Without krill, most of the life forms in the Antarctic would disappear. http://animals.nationalgeographic.com/animals/invertebrates/krill.html OMAPREM Purity Green lipped mussels Sustainably farmed in the pristine waters of New Zealand’s Marlborough Sound. Evolved to have extraordinary antioxidant content due to ozone deficiency Blue Ocean Institute, ranked New Zealand Green-lipped mussels as one of the top two ‘eco-friendly seafoods’ in the world.* *http://www.purenzgreenshell.com/aquaculture/quality-assurance/sustainability.cfm Marine Oil Extraction Process Cold press Distillation Supercritical fluid extraction Marine Oil Extraction Process Cold press and distillation processes result in bound forms of essential fatty acids Triglyceride Ethyl esters More metabolic processing required by the body in order for absorption Marine Oil Extraction Process Extraction Processes • Free Fatty Acids - easily absorbed and have been shown to have superior bioavailability* • Triglyceride form- have a triglyceride “backbone” to the grouping of Fatty Acids • Ethyl Easter- The Fatty acids are grouped together. The body must add the triglyceride backbone for absorption Free Fatty Acids Triglyceride Ethyl Easter HUMAN ABSORBTION OF FISHOIL FATIY ACIDS AS TRIACYLGLYCERLS, FREE ACIDS, OR ETHYLESTERS Tarry D. Lawson andBronwynG. Hughes Fatty Acid Absorption Ethyl Easter Form Triglyceride Form • Enzymes convert Ethyl Easter back into Triglyceride Form Glycerolysis Free Fatty Acid Form PCSO-524 Lipolysis • Lipases free the fatty acids from Triglycerides forming Micelles that contain Free Fatty Acids • Intestinal Barrier Diffusion Across Plasma Membrane Fatty Acids Reformed into Triglycerides • Particles called lipoproteins or chylomicrons • Bioavailable Released into capillaries then blood stream OMAPREM Extraction Process SFE (CO2) Patented Supercritical Fluid Extraction Dissolves nonpolar lipids from freeze dried mussel powder using combination of pressure and low temperature Process process high quantity of Free Fatty Acids OMAPREM Extraction Process Removes marine proteins Remove heavy metals no allergy no toxins Provides free fatty acid form for easy absorption into the bloodstream OMAPREM: Potency OMAPREM Potency Bioavailability The PCSO-524 oil used in OMAPREM has been shown to have 17 to 22 times more free fatty acid form DHA and EPA, in addition there are 4 novel fatty acids with greater bioactivity then standard fish oils. *Convance –Certificate of Analysis 594817-0 10-jul-2012, 594835-0,594836-0 Multiple Fatty Acids Multiple Benefits Lauric acid • PCSO-524tm contains novel fatty acids in addition to 30+ fatty acids that can reduce inflammation many times better than other anti-inflammatory supplements. Caprylic acid ALA Stearic acid • The array of fatty acids offers many unique properties not found in any other marine source Docosapentaenoic acid (DPA) Eicosatetraenoic acid (ETA) Linolenic acid Nervonic acid Fish Oils contain little more than these Fatty Acids DHA EPA Smaller & Superior One tiny capsule of OMAPREM is as powerful as 20 fish oil. Bioavailability of free fatty acid 5-10 times more in a much smaller quanitity Kataoka et al. Future Cardiol 2013; 9(2): 177-186. OMAPREM: Science Efficacy *Studies Available Upon Request Arthritis 50 patients older than 50 years Patients treated with PCSO-524™ showed a statistically significant improvement of both their pain symptoms related to osteoarthritis and improved quality of their daily lives (p = 0.05) Conclusion: Reduction of pain was statistically evident at four weeks among the subjects who took capsules that contained PCSO-524™. Practitioners can expect quicker long-term results with less risk of side effects for their osteoarthritis patients when they recommend products that contain PCSO-524™, compared with fish oil. Szechinski J et al. Measurement of pain relief resulting from the administration of Perna canaliculus lipid complex PCSO-524™ as compared to fish oil for treating patients who suffer from osteoarthritis of hip and/or knee joints. Reumatologia 2011; 49: 244-252. Visual Analog Scale (Arthritis) Week 0 Week 4 Week 8 Week 12 0.00 10.00 89% 20.00 30.00 40.00 50.00 60.00 70.00 PCSO-524 Fish Oil Quality of Life – Health Assessment Questionnaire Fish oil Mean -91% Week p < 0,05 Rheumatoid Arthritis 12 week drug monitoring study evaluated the effects of PCSO-524™ on 50 adult men and women suffering from inflammatory rheumatoid arthritis 21 of the 34 subjects (64%) reduced or terminated current drug therapy 13 patients did not require further therapy 38 % of all subjects were regarded as being free from disorders Number of subjects suffering from severe pain was significantly decreased from 60% (at baseline) to 25 % (at 3 months) A significant positive effect was observed for all investigated parameters Gruenwald J et al. Efficacy and tolerability of mussel-Lyprinol omega-3-complex on inflammatory rheumatoid disorders. PhytoPharm Research. Inflammatory Bowel Disease The effect of pretreatment with PCSO-524™ on experimentally induced inflammatory bowel disease (IBD) in mice Body weight and disease activity index (DAI) scores were recorded daily Treatment significantly reduced body weight loss, DAI scores, crypt area losses, and cecum and colon weights, compared with control Tenikoff D et al. Stabilized lipid extract of New Zealand green-lipped mussel: a potential preventative treatment modality for inflammatory bowel disease. J Gastroenterol 2005; 40: 361-365. Asthma Forty-six patients with atopic asthma received two capsules of lipid extract (PCSO-524™) or placebo b.i.d. for 8 weeks Significant decrease in daytime wheeze concentration of exhaled H2O2 Increase in morning PEF in the lipid extract group compared to the placebo group No reported significant side effects Emelyanov A, et al. Treatment of asthma with lipid extract of New Zealand greenlipped mussel: a randomized clinical trial. Eur Respir J 2002: 20: 596-600. Athletic Performance DOMS PCSO-524®, derived from the New Zealand green- lipped mussel on DOMS after a 30 km training run. One group was supplemented with 400 mg per day of PCSO-524® for 11 weeks, the other group with an olive oil placebo. Conclusion: Pain sensations experienced by distance runners following a 30 km run were reduced by supplementation with the marine oil complex PCSO524®, an effect which was greater in lesser trained runners No Known Side Effects Just Side Benefits Pharmaceutical Options like Codeine Based Pain Relievers Cortisone Immune Modulators NSAIDs (COX1, COX2) Create Side Effects Like Cartilage deterioration, osteonecrosis, nerve damage, adrenal suppression, hyperglycemia Immune suppression Addiction GI bleed, stroke, MI, renal failure The OMAPREM Advantage • OMAPREM has been shown to be up to 100 times more effective than other fish oils • OMAPREM contains complex of 30+ different fatty (Including EPA and DHA) acids. This array of fatty acids are unique to the green lipped mussel. • The fatty acids in OMAPREM are up to 22 times more free form than fish oil therefore easier for the body to absorb. • • • • 0 known side effects 0 Drug to Drug interaction 0 Contaminants 0 to Lose! OMAPREM: Partner Program Benefit Your Patients and Your Practice First Quarter Second Quarter Third Quarter Fourth Quarter First Year Total $3,150 $8,625 $13,800 $18,975 $44,550 Fifth Quarter Sixth Quarter Seventh Quarter Eighth Quarter Second Year Total $24,150 $29,325 $34,500 $39,675 $ 127,650 Chart based on 1 patient a day, a total of 25 patients each month. Ongoing Additional Quarterly Incentive Profit Per Bottle 150-225 Bottles sold per quarter $1 extra per bottle 226-300 Bottles sold per quarter $2 extra per bottle 301-up Bottles sold per quarter $3 extra per bottle $20 per 60 ct. bottle ($64.95 retail) $10 per 30 ct. bottle ($39.95 retail) For More Information www.OMAPREM.com! Order Online With Your Customized Link Your own personal page is created to ease ordering for your patients OMAPREM’s Key Points for Patients OMAPREM is a step in the right direction with improving your overall health and well being OMAPREM’s top rated customer service staff is ready to assist you Take Advantage of the End of Year Special Call our customer service line (800-725-0376). It is our intent to facilitate the most efficient and accurate way for your office to place and track orders. Order now!