2010 ageLOC Science year in review HIGHLIGHTS from the Year Nu Skin scientist Remona Gopaul accepts Nu Skin scientist Helen Knaggs, Nu Skin scientists Scott Ferguson and Steve Nu Skin and LifeGen present Young Scientist ofat the Year Award from Wood, Ph.D., and LifeGen Partner Tom at Prolla, Ph.D., speaks In-Cosmetics st World the Society of Cosmetic Chemists in CoLONGY in Barcelona, Spain Ph.D., speak at 1 Congress on Asia in Bangkok, Thailand New York Mitochondria City, USA in Berlin, Germany Targeting Berlin, Germany New York City, USA Barcelona, Spain Bangkok, Thailand ageLOC Science 2010 Timeline Conducted First pre-clinical study on ageLOC Submitted 2 Presentations Completed Presented Provisional Patent at First World Congress First heatmap validating Research at Society for on ageLOC Vitality on Targeting Mitochondria ageLOC nutritional science Investigative Dermatology JANUARY JULY OCTOBER APRIL Presented Appointed Published Launched Dr. Presented Article Stuart inKim 4Cosmetics Studies to at First ageLOC Nutrition Experimental and Toiletries Biology ‘10 Nu Skin Anti-Aging Product—ageLOC Vitality Scientific Advisory Board Presented Published Nutritional Article in JournalResearch of Cosmetic Science at Oxygen Club of Published California 2010 Article in Journal of World Congress Presented Cosmetic Dermatology Published Awarded Sponsored at CoLONGY Article in Anti-Aging DSM Nutraceutical University of Tokyo Conference Medical News Research Award Science Symposium FEBRUARY AUGUST MAY NOVEMBER SEPTEMBER MARCH JUNE DECEMBER Initiated Presented Presented Full-scale Research at clinical Biology trialof at In-Cosmetics on International Aging ageLOC Gordon Vitality Coenzyme Research Asia Conference Q Association Meeting Conference Presented at Asian Cosmetic Chemistry Society Presented Presented Awarded arNOX Research International at New Research York atat40th Young Scientist ofofthe Federation of Societies Society Annual European of Cosmetic Year by Society of Cosmetic Chemists Chemists Society Meeting Cosmeticfor Chemists Presented Dermatological Presented Youth Gene Cluster Research Presented Research arNOX Research at of at International Federation at Society of Cosmetic Societies of Cosmetic Oxygen Club of Chemists California Chemists Annual Meeting Presented 2010 World Congress at University of Tokyo Science Symposium ageLOC Science Publications and Presentations FULL LIST Posters Oral Presentations Patent Submission Awards Journal Articles March 2010 August 2010 “Antioxidation “AntioxidationNovember activities of CordyMax in an oxidative stress May 2010 Angela Mastaloudis, July 2010 Biomakers of Mitochondrial Aging and “Transcriptional March 2010and lifespan-extension activities of 2010 CordyMax in oxidative stress and aging models #A177.” model: a mechanismSenior of its anti-aging properties, Abstract Modulation by“Why Cordyceps Sinensis Cs-4.”Younger Gordon for Provisional Patent on Vitality Scientist, Received skin Dostress People response Look “Resveratrol mimics caloric restriction andofretards “A nutritional strategy to oppose the genetic “Reducing Oxidants and Antioxidants in Biology, Oxygen Club #311.” Experimental Biology ’10, April 24-28, 2010 Conference, Les Diblerets, Switzerland, August 21-27, st # 01336-36004, ORAL FORMULATIONS the DSM Nutraceutical with willow Their bark-derived Age,” Asian salicin,” Cosmetic Cosmetics aging in World the heart.” Oxidents and antioxidants aging loss of 1 2010. Wood, S.M., Barger, J., Prolla, T. A., Weindruch, California Congress, March 17-20, 2010, Santa in Anaheim, CA.expression Yang, J., Tan,ofN., Zhao,and C., Zhang, Y.,vitality.” and R., Barbara, FOR COUNTERACTING CA. Zhu, J., Zhang, Y., EFFECTS Yang, J., Tan, N., Zhao, Research Award and Toiletries Chemistry (July, Society; 2010): 32-36. Singapore, Gopaul, R., biology, Oxygen Club of California World Congress, World Congress on Targeting Mitochondria, Zhu, J. S. Mastaloudis, A., and Ferguson, S. C., and Mastaloudis, A. (presenter; received DSM Prolla, T. OF AGING. MayBarbara, 24, 2010. Knaggs,China, H., andHelen Langerveld, Knaggs.A. March 17-20,Submitted 2010, Santa CA. Strategies, Innovation and Clinical Research Award) Barger, J.L., Mastaloudis, A., Prolla, T. A., Remona Gopaul, Associate May 2010 Applications, Berlin, Germany, November 18September 2010 December 2010 Weindruch, R., and(arNOX) Wood,Implicated S.M. in Senior Scientist, Named “Appearance 19, in Japanese Women Correlates with Age- S. B., “Appearance 2010. Wood, S. M., Ferguson, in Japanese “Age-Related Oxidase September 2010 Women Correlates with the “Aging and Genes—the Link with Skin.” New York Related NADH Oxidase Levels and Blood Markers of “A Review of CurrentBoth Genomic Presence of Inosotides and Significant Aging-Related Oxidative Damage to Skin Young Scientist of the Barger, J. L., Prolla, T. A., Weindruch, R., “Impact of Scientific Lysolipids, Innovations on the Society of Cosmetic Meeting, Lipid Oxidation,” Society for Investigative Dermatology; J. Inhibitors of Age-Related NADH Oxidase Levels,” 40th Proteins,”Oxygen Club of Chemists California, 2010 World Helen Knaggs. Techniques Used in Gene Year by the Society of and Bartlett, M. Personal Care Industry,” Journal of Cosmetic Invest Dermatol 130. S. 6 (2010). Morré, D. J., Morré, D. Annual European Society forProfiling Dermatological Congress, Santa Barbara, California. Morré, D. M., Morré, Expression of theResearch, Skin,” Science, 9(3)D.2010; 260-263. Knaggs, M., Kern, D. G., and Cosmetic Wood, S. M.Chemists June 2010. Morrѐ, J., Morrѐ, D. M., Kern, D. G., H. Wood, D. J., Meadows, C., Draelos, Z., and of Cosmetic Chemists “Targeting age-related gene expression S. M., Toyoda,Society June H., and Knaggs, H. Kern, D.2010 G. Annual Meeting; New York, New improves mental and physicalwith vitality.” 1st “Transcriptional Biomarkers of Mitochondrial Aging“Regulating and the Expression of Genes Associated the “An evaluation of the effect of a topical April 2010 York,ofRemona Congress on Targeting Modulation by Cordyceps Sinensis Cs-4.” Gordon Synthesis andWorld Maintenance of Dermal Hyaluronan Mitochondria, and “Anti-Aging Effects SuperoxideGopaul. Reduction in Skin by the “CordyMax extends the lifespan in an aging model: a product containing salicin Barrier Lipids Strategies, Via Topical Treatment of Salicin—An In Application of Specific Inhibitors of Age-Related NADH Innovation and Clinical Conference, Les Diblerets, Switzerland, August 21-27, preliminary report, Abstract #A310.” Experimental Biology Vitro Analysis,” Society for Investigative Dermatology; J. on the visibleInternational signs of human skinof aging,” Oxidase (arNOX),” Federation Societies of Applications, Berlin, Germany, November 182010. S.M.,Anaheim, Barger,CA. J.,Tan, Prolla, T. A., Y., Weindruch, ’10, AprilWood, 24-28, 2010 N., Zhang, Invest Dermatol 130. S. 84 (2010). Gopaul, R. and Cosmetic Chemists, Buenos Dermatology, Aires, Argentina. 9(3) Kern, 2010; D. G., Journal of Cosmetic Yang, J., Zhao, C., and S. R., Mastaloudis, A.,Zhu, andJ.Ferguson, S. Knaggs, H. 19, 2010. Ferguson, S. B., Tan, N., Dong, Y., Meadows, C., Fuller, B. B., Knaggs, H., Morrѐ, D. M., and 196-201. Gopaul, R., Gibson, M., Knaggs, Lu, J., Fisk, N.A., Wood, S.M., Zhu, J., andMorrѐ, D. J. “Improvement of exercise metabolism and carotenoid H., Holley, K.C., and Lephard, J. Bartlett, M. “Salicin Regulates the Expression of ‘Functional Youth antioxidant scores with CordyMax and LifePak in young September 2010 Gene Clusters’ to Reflect a More Youthful Skin Profile,” “Salicin Reduces the Expression of Genes Associated with Chinese elite athletes, “Mitochondria and Abstract Aging.”#D356.” Japan Experimental Symposium. International Federation of Societies Cosmetic “Genes and Aging: ofLinks to Skin,” SkinDecember Inflammation—An Biology ’10, April 24-28, 2010 Anaheim, CA. Duan, L., 2010In Vitro Analysis,” Society for Mechanisms of Ageing andL.,Development Chemists Annual Meeting, Buenos Aires, Argentina. Investigative Dermatology; J. Invest Dermatol 130. S. 85 Zhao, L., Liang, C., Lu, L., Gao, Li, G., and Zhu, 2010;13:449J.S. In-Cosmetics Asia; Bangkok, Thailand, “Nutritional and genetic strategies for Gopaul, R., Langerveld, A., Knaggs, H., and Lephart, J. 450;480-486. Prolla, T. (2010). Gopaul, R. and Knaggs, H. Helen Knaggs. longevity.” Anti-Aging Medical News. Winter “Maturational alteration of differential expressions 2010:36-40. Bartlett, M. “Inhibition by Coenzyme Q10 of Age Related Oxidase of GC:AT-biased genotypes of Cordyceps sinensis fungi and Paecilomyces hepiali in Cordyceps sinensis, Abstract #B210.” Experimental Biology ’10, April 24-28, 2010 Anaheim, CA. Zhu, J. S., Gao, L., Yao, Y., and Zhou, Y. (arNOX) Caused Oxidative Damage in Skin Proteins,” International Coenzyme Q Association Meeting, Brussels, Belgium. Morré, D. M., Morré, D. J., Meadows, C., Draelos, Z., and Kern, D. G. summary Nu Skin scientists and our scientific partners have just concluded a breakthrough year, building our body of knowledge in anti-aging research at an accelerating rate with more than 20 presentations at 11 prestigious conferences and symposia around the world. We believe Nu Skin’s ongoing research, combined with our research partnerships, including LifeGen Technologies, will deepen the company’s understanding of gene expression and its impact on reversing the effects of aging even later in life. We believe ageLOC science is the answer to anti-aging. It’s a scientific breakthrough that goes beyond the signs to target the ultimate sources of aging. For more information about ageLOC science, please visit ageloc.com.