Presented

Report
2010
ageLOC Science
year in review
HIGHLIGHTS
from the Year
Nu
Skin
scientist
Remona
Gopaul
accepts
Nu
Skin
scientist
Helen
Knaggs,
Nu Skin scientists Scott Ferguson and Steve
Nu
Skin
and
LifeGen
present
Young
Scientist
ofat
the
Year
Award
from
Wood,
Ph.D.,
and LifeGen
Partner
Tom at
Prolla,
Ph.D.,
speaks
In-Cosmetics
st World
the
Society
of
Cosmetic
Chemists
in
CoLONGY
in
Barcelona,
Spain
Ph.D.,
speak
at
1
Congress
on
Asia in Bangkok, Thailand
New
York Mitochondria
City, USA in Berlin, Germany
Targeting
Berlin, Germany
New York City, USA
Barcelona, Spain
Bangkok, Thailand
ageLOC Science
2010 Timeline
Conducted
First pre-clinical
study on ageLOC
Submitted
2 Presentations
Completed
Presented
Provisional
Patent
at First
World
Congress
First
heatmap
validating
Research
at
Society
for
on
ageLOC
Vitality
on
Targeting
Mitochondria
ageLOC
nutritional
science
Investigative
Dermatology
JANUARY
JULY
OCTOBER
APRIL
Presented
Appointed
Published
Launched
Dr.
Presented
Article
Stuart
inKim
4Cosmetics
Studies
to
at
First
ageLOC
Nutrition
Experimental
and
Toiletries
Biology
‘10
Nu
Skin
Anti-Aging
Product—ageLOC
Vitality
Scientific Advisory Board
Presented
Published
Nutritional
Article
in JournalResearch
of
Cosmetic
Science
at Oxygen
Club of
Published
California 2010
Article
in Journal
of
World
Congress
Presented
Cosmetic
Dermatology
Published
Awarded
Sponsored
at CoLONGY
Article
in Anti-Aging
DSM
Nutraceutical
University
of
Tokyo
Conference
Medical
News
Research
Award
Science Symposium
FEBRUARY
AUGUST
MAY
NOVEMBER
SEPTEMBER
MARCH
JUNE
DECEMBER
Initiated
Presented
Presented
Full-scale
Research
at
clinical
Biology
trialof
at In-Cosmetics
on
International
Aging
ageLOC
Gordon
Vitality
Coenzyme
Research
Asia
Conference
Q Association Meeting
Conference
Presented
at Asian Cosmetic
Chemistry Society
Presented
Presented
Awarded
arNOX
Research
International
at New
Research
York
atat40th
Young
Scientist
ofofthe
Federation of Societies
Society
Annual
European
of
Cosmetic
Year by
Society of
Cosmetic
Chemists
Chemists
Society
Meeting
Cosmeticfor
Chemists
Presented
Dermatological
Presented
Youth
Gene Cluster Research
Presented
Research
arNOX
Research
at of
at International
Federation
at Society
of
Cosmetic
Societies
of Cosmetic
Oxygen
Club
of Chemists
California
Chemists
Annual
Meeting
Presented
2010 World Congress
at University of Tokyo
Science Symposium
ageLOC Science
Publications and
Presentations
FULL LIST
Posters
Oral
Presentations
Patent
Submission
Awards
Journal Articles
March 2010
August 2010
“Antioxidation
“AntioxidationNovember
activities
of CordyMax
in an oxidative stress
May
2010
Angela
Mastaloudis,
July 2010 Biomakers of Mitochondrial Aging and
“Transcriptional
March
2010and lifespan-extension activities of
2010
CordyMax in oxidative stress and aging models #A177.”
model: a mechanismSenior
of its anti-aging
properties,
Abstract
Modulation
by“Why
Cordyceps
Sinensis
Cs-4.”Younger
Gordon for
Provisional
Patent
on
Vitality
Scientist,
Received
skin
Dostress
People
response
Look
“Resveratrol
mimics caloric
restriction
andofretards
“A nutritional strategy to oppose the genetic “Reducing
Oxidants and Antioxidants
in Biology,
Oxygen Club
#311.” Experimental Biology ’10, April 24-28, 2010
Conference, Les Diblerets, Switzerland, August 21-27,
st
#
01336-36004,
ORAL
FORMULATIONS
the
DSM
Nutraceutical
with
willow
Their
bark-derived
Age,”
Asian
salicin,”
Cosmetic
Cosmetics
aging
in World
the heart.”
Oxidents
and antioxidants
aging
loss of
1 2010. Wood, S.M., Barger, J., Prolla, T. A., Weindruch,
California
Congress,
March 17-20,
2010, Santa in Anaheim, CA.expression
Yang, J., Tan,ofN.,
Zhao,and
C., Zhang,
Y.,vitality.”
and
R.,
Barbara,
FOR
COUNTERACTING
CA.
Zhu,
J.,
Zhang,
Y.,
EFFECTS
Yang,
J.,
Tan,
N.,
Zhao,
Research
Award
and
Toiletries
Chemistry
(July,
Society;
2010):
32-36.
Singapore,
Gopaul, R.,
biology, Oxygen Club of California World Congress,
World Congress on Targeting Mitochondria,
Zhu, J. S.
Mastaloudis, A., and Ferguson, S.
C.,
and
Mastaloudis,
A. (presenter;
received
DSM Prolla, T.
OF
AGING.
MayBarbara,
24,
2010.
Knaggs,China,
H., andHelen
Langerveld,
Knaggs.A.
March
17-20,Submitted
2010,
Santa
CA.
Strategies, Innovation and Clinical
Research Award)
Barger, J.L., Mastaloudis, A., Prolla, T. A.,
Remona
Gopaul,
Associate
May 2010
Applications, Berlin, Germany, November 18September 2010
December
2010
Weindruch,
R., and(arNOX)
Wood,Implicated
S.M. in
Senior
Scientist,
Named
“Appearance 19,
in Japanese
Women
Correlates
with Age- S. B., “Appearance
2010.
Wood,
S.
M.,
Ferguson,
in Japanese
“Age-Related Oxidase
September
2010 Women Correlates with the
“Aging and Genes—the Link with Skin.” New York Related NADH Oxidase Levels and Blood Markers of
“A
Review
of
CurrentBoth
Genomic
Presence
of
Inosotides
and
Significant
Aging-Related Oxidative Damage to Skin
Young
Scientist
of
the
Barger, J. L., Prolla, T. A., Weindruch, R.,
“Impact of Scientific Lysolipids,
Innovations
on
the
Society
of Cosmetic
Meeting,
Lipid Oxidation,” Society for Investigative Dermatology; J.
Inhibitors of Age-Related
NADH
Oxidase
Levels,” 40th
Proteins,”Oxygen
Club of Chemists
California, 2010
World Helen Knaggs.
Techniques
Used
in
Gene
Year
by
the
Society
of
and
Bartlett,
M.
Personal
Care
Industry,”
Journal
of
Cosmetic
Invest Dermatol 130. S. 6 (2010). Morré, D. J., Morré, D.
Annual European
Society forProfiling
Dermatological
Congress, Santa Barbara, California. Morré, D. M., Morré,
Expression
of theResearch,
Skin,”
Science,
9(3)D.2010;
260-263.
Knaggs,
M., Kern, D. G., and Cosmetic
Wood, S. M.Chemists
June
2010. Morrѐ,
J., Morrѐ,
D. M., Kern,
D. G., H.
Wood,
D. J., Meadows, C., Draelos, Z., and
of Cosmetic
Chemists
“Targeting age-related gene expression S. M., Toyoda,Society
June
H., and Knaggs,
H.
Kern, D.2010
G.
Annual Meeting; New York, New
improves
mental
and
physicalwith
vitality.”
1st
“Transcriptional Biomarkers of Mitochondrial Aging“Regulating
and
the
Expression
of Genes
Associated
the
“An evaluation
of the effect of a topical
April
2010
York,ofRemona
Congress
on Targeting
Modulation by Cordyceps Sinensis Cs-4.” Gordon Synthesis andWorld
Maintenance
of Dermal
Hyaluronan Mitochondria,
and
“Anti-Aging Effects
SuperoxideGopaul.
Reduction in Skin by the
“CordyMax extends the lifespan in an aging model: a
product
containing
salicin
Barrier Lipids Strategies,
Via Topical Treatment
of Salicin—An
In
Application of Specific Inhibitors
of Age-Related NADH
Innovation
and
Clinical
Conference,
Les
Diblerets,
Switzerland,
August
21-27,
preliminary report, Abstract #A310.” Experimental Biology
Vitro Analysis,” Society for Investigative Dermatology; J.
on the
visibleInternational
signs of human
skinof aging,”
Oxidase
(arNOX),”
Federation
Societies of
Applications, Berlin, Germany, November 182010.
S.M.,Anaheim,
Barger,CA.
J.,Tan,
Prolla,
T. A., Y.,
Weindruch,
’10, AprilWood,
24-28, 2010
N., Zhang,
Invest Dermatol 130. S. 84 (2010). Gopaul, R. and
Cosmetic
Chemists,
Buenos Dermatology,
Aires, Argentina. 9(3)
Kern, 2010;
D. G.,
Journal
of
Cosmetic
Yang,
J., Zhao, C., and
S.
R., Mastaloudis,
A.,Zhu,
andJ.Ferguson,
S.
Knaggs, H. 19, 2010. Ferguson, S. B., Tan, N., Dong, Y.,
Meadows, C., Fuller, B. B., Knaggs, H., Morrѐ, D. M., and
196-201.
Gopaul,
R.,
Gibson,
M.,
Knaggs,
Lu, J., Fisk, N.A., Wood, S.M., Zhu, J., andMorrѐ, D. J.
“Improvement of exercise metabolism and carotenoid
H., Holley, K.C., and Lephard, J.
Bartlett,
M.
“Salicin
Regulates
the Expression
of ‘Functional Youth
antioxidant scores
with CordyMax and LifePak in young
September
2010
Gene
Clusters’
to
Reflect
a
More
Youthful
Skin
Profile,”
“Salicin Reduces the Expression of Genes Associated with
Chinese
elite athletes,
“Mitochondria
and Abstract
Aging.”#D356.”
Japan Experimental
Symposium.
International Federation
of Societies
Cosmetic
“Genes and
Aging: ofLinks
to Skin,”
SkinDecember
Inflammation—An
Biology ’10, April 24-28, 2010 Anaheim, CA. Duan, L.,
2010In Vitro Analysis,” Society for
Mechanisms
of Ageing
andL.,Development
Chemists Annual Meeting, Buenos Aires, Argentina.
Investigative Dermatology; J. Invest Dermatol 130. S. 85
Zhao, L., Liang, C.,
Lu, L., Gao,
Li, G., and Zhu, 2010;13:449J.S.
In-Cosmetics Asia; Bangkok, Thailand,
“Nutritional
and genetic strategies for
Gopaul, R., Langerveld, A., Knaggs, H., and Lephart, J.
450;480-486. Prolla, T.
(2010). Gopaul, R. and Knaggs, H.
Helen Knaggs.
longevity.” Anti-Aging Medical News. Winter
“Maturational alteration of differential expressions
2010:36-40. Bartlett, M.
“Inhibition by Coenzyme Q10 of Age Related Oxidase
of GC:AT-biased genotypes of Cordyceps sinensis fungi
and Paecilomyces hepiali in Cordyceps sinensis, Abstract
#B210.” Experimental Biology ’10, April 24-28, 2010
Anaheim, CA. Zhu, J. S., Gao, L., Yao, Y., and Zhou, Y.
(arNOX) Caused Oxidative Damage in Skin Proteins,”
International Coenzyme Q Association Meeting, Brussels,
Belgium. Morré, D. M., Morré, D. J., Meadows, C.,
Draelos, Z., and Kern, D. G.
summary
Nu Skin scientists and our scientific partners have just concluded a
breakthrough year, building our body of knowledge in anti-aging research at an
accelerating rate with more than 20 presentations at 11 prestigious conferences
and symposia around the world.
We believe Nu Skin’s ongoing research, combined with our research
partnerships, including LifeGen Technologies, will deepen the company’s
understanding of gene expression and its impact on reversing the effects of
aging even later in life.
We believe ageLOC science is the answer to anti-aging. It’s a scientific
breakthrough that goes beyond the signs to target the ultimate sources of aging.
For more information about ageLOC science, please visit ageloc.com.

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