Helping Promote Vaccination HPV-Related Cancers Problem Space Sabita Saldanha, Alabama State University Tamara McEwen, Southwestern College BioQUEST 2013 Summer Workshop Emory University 15 June 2013 Introduction to HPV Problem Set Target Audience: • Introductory Undergraduate Courses • Biology, Microbiology, Immunology, Public Health Objectives: • To increase data literacy through graphical analysis • To examine the impact of socioeconomic status and the economic factors on HPV incidence and mortality rates • To increase ethical reasoning skills regarding the possibility of mandatory vaccinations Biological Principles: • Certain viruses cause cancer. • HPV causes many cancers including cervical, anal, penile, vaginal, and oropharyngeal. • HPV-16 and HPV-18 are responsible for an overwhelming majority of these cancers. https://www.youtube.com/watch?feature=player_embedded&v=ClD1gnX nl-E • Vaccination can prevent most virally-induced cancers. Analysis Tools and Activities Graphical Analysis • Excel • Gapminder • Google Charts 1. 2. 3. 4. Sequence Analysis 5. • CaseIT with BLAST or tree Interpret Figure A (Lowy & Schilling), includes written description and class discussion Cancer Prev Res 2012 Jan 5(1) 18-23, Figure 1.ppt Compare and contrast incidence and mortality rates of cervical cancer (developed vs developing) by graphing. Tables 4 and 5 WHO.pptx Analyze future projections of incidence and mortality rates by graphing. Figures 10 and 16 WHO.pptx Write opinion summary accepting or rejecting data in favor of vaccination, which includes opinion regarding mandatory vaccination. Compare and contrast various sero-types of HPV based on sequence alignment. Bibliography • • • • • • • • • CaseIT Project© University of Wisconsin-River Falls. 2012. Date Accessed 14 Jun 2013. Available at www.caseitproject.org. Human Papillomavirus (HPV): What is HPV? Centers for Disease Control and Prevention, USA.gov. 5 Feb 2013. Date Accessed 13 Jun 2013. Available at www.cdc.gov/hpv/whatishpv.html. Human Papillomavirus (HPV): HPV Vaccines. What is Centers for Disease Control and Prevention, USA.gov. 5 Feb 2013. Date Accessed 13 Jun 2013. Available at www.cdc.gov/hpv/vaccine.html. Jaslow, Ryan. Oral Sex and Throat Cancer: Michael Douglas HPV report spotlights “epidemic”. 5 Feb 2013. 3 Jun 2013. Date Accessed 13 Jun 2013. Available at www.cbsnews.com/8301-204_16257587350/oral-sex-and-throat-cancer-michael-douglas-hpv-report-spotlights-epidemic. Lowy, Douglas R. and Schiller, John T. Reducing HPV-Associated Cancer Globally. Cancer Prev Res 2012 5:18-23. Molina, Gaby. Infeccion por PVH. 13 Mar 2010. Date Accessed 13 Jun 2013. Available at www.youtube.com/watch?feature=player_embedded&v=ClD1gnXnl-E. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, and Kumar S (2011) MEGA5: Molecular Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum Parsimony Methods. Molecular Biology and Evolution 28: 2731-2739. MEGA, Software accessed 14 Jun 2013. Available at http://megasoftware.net. Viruses and Cancer. CancerQuest. Winship Cancer Institute, Emory University. 2013. Date Accessed 13June2013. Available at www.cancerquest.org/viruses-cancer.html. WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human Papillomavirus and Related Cancers in World Summary Report 2009. Date Accessed 10Jun2013. Available at www.who.int/hpvcentre.