Cancer Prev Res

Helping Promote Vaccination
HPV-Related Cancers Problem Space
Sabita Saldanha, Alabama State University
Tamara McEwen, Southwestern College
BioQUEST 2013 Summer Workshop
Emory University
15 June 2013
Introduction to HPV Problem Set
Target Audience:
• Introductory Undergraduate Courses
• Biology, Microbiology, Immunology, Public Health
• To increase data literacy through graphical analysis
• To examine the impact of socioeconomic status and the economic factors
on HPV incidence and mortality rates
• To increase ethical reasoning skills regarding the possibility of
mandatory vaccinations
Biological Principles:
• Certain viruses cause cancer.
• HPV causes many cancers including cervical, anal, penile, vaginal, and
• HPV-16 and HPV-18 are responsible for an overwhelming majority of
these cancers.
• Vaccination can prevent most virally-induced cancers.
Analysis Tools and Activities
Graphical Analysis
• Excel
• Gapminder
• Google Charts
Sequence Analysis
• CaseIT with BLAST
or tree
Interpret Figure A (Lowy & Schilling), includes written
description and class discussion Cancer Prev Res
2012 Jan 5(1) 18-23, Figure 1.ppt
Compare and contrast incidence and mortality rates
of cervical cancer (developed vs developing) by
graphing. Tables 4 and 5 WHO.pptx
Analyze future projections of incidence and mortality
rates by graphing. Figures 10 and 16 WHO.pptx
Write opinion summary accepting or rejecting data in
favor of vaccination, which includes opinion regarding
mandatory vaccination.
Compare and contrast various sero-types of HPV
based on sequence alignment.
CaseIT Project© University of Wisconsin-River Falls. 2012. Date Accessed 14 Jun 2013. Available at
Human Papillomavirus (HPV): What is HPV? Centers for Disease Control and Prevention, 5
Feb 2013. Date Accessed 13 Jun 2013. Available at
Human Papillomavirus (HPV): HPV Vaccines. What is Centers for Disease Control and Prevention, 5 Feb 2013. Date Accessed 13 Jun 2013. Available at
Jaslow, Ryan. Oral Sex and Throat Cancer: Michael Douglas HPV report spotlights “epidemic”. 5 Feb
2013. 3 Jun 2013. Date Accessed 13 Jun 2013. Available at
Lowy, Douglas R. and Schiller, John T. Reducing HPV-Associated Cancer Globally. Cancer Prev Res 2012
Molina, Gaby. Infeccion por PVH. 13 Mar 2010. Date Accessed 13 Jun 2013. Available at
Tamura K, Peterson D, Peterson N, Stecher G, Nei M, and Kumar S (2011) MEGA5: Molecular
Evolutionary Genetics Analysis using Maximum Likelihood, Evolutionary Distance, and Maximum
Parsimony Methods. Molecular Biology and Evolution 28: 2731-2739. MEGA, Software accessed 14
Jun 2013. Available at
Viruses and Cancer. CancerQuest. Winship Cancer Institute, Emory University. 2013. Date Accessed
13June2013. Available at
WHO/ICO Information Centre on HPV and Cervical Cancer (HPV Information Centre). Human
Papillomavirus and Related Cancers in World Summary Report 2009. Date Accessed 10Jun2013.
Available at

similar documents