Gustavo Stolovitzky, Chair Alex Pico, Barry Demchak, Trey Ideker Andrea Califano, Chair Christina Leslie, Lonnie Welch, Chairs Manolis Kellis, Chair Steven Leard, Chris Williams 13 Keynote Speakers 63 Oral communications 152 Posters 4 Workshops (2 Cytoscape + 2 DREAM) DREAM: 368 challenge submissions Great demand from colleagues wishing to share their data challenges led us to organize winter (n+0.5) and spring challenges (n+1) 8.5 + 9 A Dialogue on Reverse Engineering Assessment and Methods DREAM was a component of several grants funded in 2014 U54 NIH LINCS Program: • Harvard Medical School: Pharmaco Response Signatures and Disease Mechanism • OHSU: Extrinsic Perturbations of Cell Physiology and Associated Regulatory Networks U54 DCIC: • ISMMS: Data Coordination and Integration Center for LINCS-BD2K Canada NSERC • Cancer Genome Collaboratory (the Somatic Mutation Challenges) R21: • Univ of Notre Dame: Transcript networks and crowdsourcing to predict drug combinations in malaria parasites And we are also involved in several other submitted grants • We organized the first DREAM Hackathon for the AML Challenge at Rice University • Organized over 15 Webinars • Two community phases following the competitive phase DREAM 8.5 and 9 exceeded previous participation Number of Submitting Teams 400 350 300 250 200 150 100 50 0 DREAM Participation Challenges DREAM 8.5 + 9 SMC Registered Users 360 Leader board 1094 Forum Entries 120 Unique Submissions 173 Unique Teams 50 RA 369 4914 52 32 21 AD 520 1972 80 43 24 AML 231 583 184 72 42 GEP 300 2896 233 48 22 Total 1780 11459 669 368 159 Our association has led to a very productive year Feb 2013 SYNAPSE IS ENHANCING ITS CHALLENGE HOSTING CAPABILITYIES Come to the Workshop Tuesday at 6:45PM (pizza & drinks on us) Synapse: collaborative platform for DREAM Challenges and much more http://dreamchallenges.org/ 2014 DREAM PUBLICATIONS NCI - DREAM Drug Sensitivity Prediction Challenge (Jun 2014) NCI - DREAM Drug Synergy Prediction Challenge (Dec 2014) 2014 DREAM PUBLICATIONS DREAM 7 - ALS Progression Prediction Challenge (Nov 2014) DREAM6+7: Net Inf & Param Estimation Challenge (Feb 2014) 2014 DREAM PUBLICATIONS We are organizing several Challenges that we will discuss later today (more info in dreamchallenges.org) DREAM 9.5 (this winter) ICGC-TCGA DREAM SMC Challenges: RNA and heterogeneity DREAM Olfaction prediction Challenge Prostate Cancer Challenge DREAM10 (work in progress, next spring) ALS Stratification Challenge (Indiegogo campaign) Drug Synergy Prediction Challenge Digital Mammography Challenge Thanks: Conference Sponsors and Journals Challenge Organizers Too many thanks to express… The 159 teams that participated and Thea Norman! • There is a crew making a short video on DREAM. Let us know if you don’t want to appear in it. • There is a board for posting information, jobs, etc. Take a look (I am looking for a post-doc). • There will be a workshop at 6:00PM today, and another at 6:45PM tomorrow. Please write your name in the sheets that are going around to know how many pizzas and beer to order!