NTP Radioisotopes SOC Ltd A subsidiary of Necsa Ltd Pelindaba, South Africa NTP’S ROLE IN NUCLEAR MEDICINE GLOBALLY AND COOPERATION WITH BELGIUM Mapula Letsoalo 2013 October 23 www.ntp.co.za Depleted Uranium Fabrication NTP Radioisotopes (Pty) Ltd Facility (Pelindaba) Contents • Role in global Mo-99 supply • Role in SA nuclear medicine • Continued relations with IRE Geographical GeographicalLocation LocationofofNTP NTPRadioisotopes Radioisotopes Pretoria NTP located at the Necsa Pelindaba Site OR Tambo Soweto Johannesburg The Real And Lasting Victories Are Those Of Peace In 1991, the South African government signed the Non-Proliferation Treaty (NPT) and became the first and only nation to voluntarily declare and dismantle its nuclear weapons And they shall beat their swords into ploughshares ... – Isaiah 2:4 Mo-99 Production & Related Facilities 5 3 1 4 2 1 2 3 4 5 - Radiochemical Production Plant Commercial Office Radiopharmaceutical Production Plant Radioanalytical Labs SAFARI-1 SAFARI-1 Reactor Nuclear Reactor Mo-99 Production at NTP Enriched Uranium Inventory Fuel Production Plant Nuclear Fuel Assemblies SAFARI-1 Reactor Target Plate Irradiation Target Plates Irradiated plates Depleted Uranium Inventory Waste Nuclear Waste Management Radiochemical Production Plant Chemical Extraction and purification of Mo-99 Waste Disposal & Storage Facilities Transport Container Design Manufacture, License NTP Generator Manufacture International Market Local & International Users NTP -Product Portfolio IRE Cooperation • Collaborative partnership since 1997 • Mo-99 Supply crisis • Increased production output Mo-99 Supply - Crisis Conditions ARI 5% NTP 40% IRE 30% Covidien 25% Total: 8 000 Ci/week RadioisotopeSource Source Containers Containers Radioisotope Depleted uranium fabrication facility Radiochemical Transport Containers (1 500 Ci Mo-99, 125kg) Subsidiary Subsidiary Companies Company NTP Logistics is a joint venture company between NTP Radioisotopes (51 %) and a BEE partner Specialize in managing the logistics of dangerous goods including radioactive materials. NTP ProductofPortfolio Conversion Mo-99 Production to LEU 2011 •Routine supply of LEU Mo-99 (June) 2010 2009 2008 •Cold and depleted uranium experiments 2007 •Theoretical feasibility studies •NNR approval received for test stage •Hot runs commence •Submission to Regulators (June) •Validation runs (July) •NNR approval routiine ops (Sept) •FDA approval for use in US (Nov) Medicals Facilities Medical Facility 3 3 22 1 1 1 2 3 - Medicals & Industrials SAFARI-1 Cyclotron facility Nuclear Medical Isotopes & Related Products Radiopharmaceuticals Radiopharmaceuticals NovaTec-P Tc-99m Generator, Cold kits F-18 FDG I-131 Capsules, Solution and MIBG New Lu-177 dotatate F-Choline Subsidiary Companies Company NTP has a 100% shareholding in AECAmersham SOC Ltd Exclusive distributor in Africa of NTP's radiopharmaceutical products as well as a range of life science research and other products. Corporate Social Investment PET/CT Scanner donated to people of Western Cape Located at Tygerberg PET/CT Centre Official opening - April 2012 Subsidiary SubsidiaryCompanies Company Fully-owned subsidiary company NTP Radioisotopes (Europe) S.A. Established on 1 February 2013 Located in Belgium – IRE site Manufacturer and distributor of gamma-radiography equipment used in the nondestructive testing (NDT) industry, including sealed radioactive sources containing Ir192, Se-75 and Co-60, as well as the GammaMat range of NDT projectors and accessories Also manufactures a range of Ir-192 brachytherapy products Subsidiary ConclusionCompanies Necsa/ NTP’s nuclear technology is making a major contribution to the economy and to our country’s global standing. Subsidiary Companies Thank you very much!