Presentation to: Office of the Assistant Secretary of the

Report
H2O2 Solutions LLC
Binary
Ionization
Technology
Systems
This technical data is controlled under the U.S. International Traffic in Arms
Regulations (ITAR) and may not be exported to a Foreign Person, either in the
U.S. or abroad, without the proper authorization by the U.S. Department of State.
Binary Ionization Technology Systems
Energized Chemistry - H2O2
Ionization:
BIT Plasma Head
Cold Plasma (BIT Plasma)
UV Light, heat, ozone
Chemical Activation (BIT Chemical)
Basic Chemical Reaction:
H2O2 + activator peroxy acids + hydroxyls,
reactive oxygen species (ROS)
Redox potential greater than chlorine or
peroxide alone
What it Does:
Destroys proteins on contact (via oxidation)
killing biological agents including viruses,
molds, bacteria and bacterial spores
Reacts with chemical bonds in chemical
agents destroying their activity
This technical data is controlled under the U.S. International Traffic in Arms
Regulations (ITAR) and may not be exported to a Foreign Person, either in the
U.S. or abroad, without the proper authorization by the U.S. Department of State.
BIT Mobile Control Units
What is the BIT Plasma
System?
 Aerosolized solution
containing hydrogen
peroxide
 Electric arc produced by
17K volt potential
 Hydrogen peroxide,
nitrogen and oxygen are
energized (ionized)
 Creates a variety of “free
radicals” including:
Hydroxyl radical
Hydroxyl ion
Superoxide anion
Singlet oxygen
Other reactive oxygen
species (ROS)
Reactive Oxygen Species (ROS) Destroy Chemical
Bonds, Disrupting Proteins, Lipids and Chemicals
GA
VX
DPCP
This technical data is controlled under the U.S. International Traffic in Arms
Regulations (ITAR) and may not be exported to a Foreign Person, either in the
U.S. or abroad, without the proper authorization by the U.S. Department of State.
BIT Plasma System Commercial Product
SteraMist Fogging Unit
Primary use is to decontaminate
surfaces in tissue banks, hospitals
and pharmaceutical manufacturing
facilities
Extensive in-house and 3rd party
testing against a wide range of
pathogens
Production of commercial units and
sales began in September 2008
Use of extendable ‘pods’ allow for
flexibility of mist application
This technical data is controlled under the U.S. International Traffic in Arms
Regulations (ITAR) and may not be exported to a Foreign Person, either in the
U.S. or abroad, without the proper authorization by the U.S. Department of State.
Extensive Testing Against Biologicals
In-house and
multiple 3rd party tests
Exposure times 15-90 seconds
Killing up to 9 logs
Effective against mold, spores,
viruses and bacteria
BIT Plasma Advantages
 Broad spectrum including bacterial and
fungal endospores
 ROS kill by lysis of cell walls
 Rapid cycle time
 Environmentally friendly-residue
H2O+O2
 H2O2 concentration of 7.5% is safe for
personnel
 No damage to interior materials
 Electrostatic spray extensive distribution
 Log kill organisms >6 for all organisms
tested
How Common Is MRSA?
Jarvis, et al,”National
Prevalence of MRSA in
Inpatients in Health Care
Facilities,2006,” AJIS, vol35#10,
12-07
P > 46.3/1000 inpatients ( 34
infect and 12 colonization /1000
inpatients )
The Value of a Clean Environment
 Huang et al, “The Risk of Aquiring Antibiotic
Resistant Bacteria From Prior Room Occupants,”
Arch of Int Med, vol 166#18, 10-06
 Drees et al,”Prior Environmental
ContaminationIncreases the Risk of Acquisition
of Vancomycin-Resistant Enterococci,” Clin Infect
Dis, vol 46 #2, 3-08
 Otter et al,”Survival of Nosocomial Bacteria and
Spores on Surfaces and Inactivation by H2O2
Vapour,”J Clin Microbiol, vol47#2, 2-09
How Important is the Environment
 Harris, Anthony, “Editorial: How
important is the environment inj the
Emergence of Nosocomial Antibiotic
Resistant Bacteria?,” Clin Infect Dis,
vol 46#2 3-08
 While patient to patient transmission
via health care workers is an
important mechanism, the role of
environmental contamination appears
significant
Does Disinfection Reduce Risk?
Deterkofer et al,” Does Disinfection of
Environmental Surfaces Influence
Nosocomial Infection Rates? AIIC vol 32
#2, 4-04
Are Conventional Techniques Adequate?
 Carling et al,”Intensive Care Unit Environmental
Cleaning: An Evaluation of Sixteen Hospitals
Using a Novel Assessment tool,” J of Hosp Infect,
vol 68, 1-08
 Goodman et al,”Impact of Environmental
Cleaning Intervention on the Presence of MRSA
and VRE on Surfaces in Intensive Care Unit
Rooms,” Infec Control and Hosp Epi, vol29#7,
7-08
Is Infection Control Cost Effective?
Perencevich et al, “Raising Standards While
Watching the Bottom Line: Making a
Business Case for Infection Control,” Infect
Control and Hosp Epi, vol 28#10, 10-07
Is H2O2 Decontamination Effective, Safe,
and Practical? (Steris )
Boyce,John M.,”New
Approaches to
Decontamination of Rooms,”
Infec Control and After
Patients Are Discharged
Hosp Epi, vol30#5 6-09
BIT Plasma H2O2 vs Steris-VHP
 Charged Aerosol
 In or outside
 No special Tx
 Surface activity
 No prep
 Active
immediately
 OK with HVAC
 Redox =2.8
(fl=3.0)
 Need optimal dry-conditions
 Inside
 No surface
activity
 Hours to prep
 Needs 30’
exposure
 Corrodes HVAC
duct
 Redox H2O2 =1.8
BIT Plasma vs Steris VHP
 Spread enhanced
by charged
particles
 Std bio indicator
 Rapidly H2O +O2
 Safe with metals
 H2O2 conc 7% is
non toxic ( except
eye)
 Fabric/cellulose
OK
 Limited
penetration b/o
moisture effect
 Special SS
indicator
 Slow
decomp ,Hard to
monitor
 Oxidizes metals
 H2O2 conc 50%toxic to lungs skin
eye
 Fabric-cellulose
separate decontam
Verification
3M Clean Trace ATP System
Biological Indicators: Geobacillus
stearothemophilus (incubated at
55-60 degrees C, in Trypticase
Soy Broth)
H2O2 Solutions
Sterilization Services
BIT SteraMist Sales
Objective - Services
To drastically reduce the index and
related costs of hospital-acquired
infections by efficiently sterilizing the
areas where dangerous pathogens are
normally found.
Advantages
Reduction of operational costs (room
turn-around times).
Reduction of functional costs (changes
in Medicare).
Reduction in exposure to litigious
events.
More active protection of patients, staff,
and visitors.
H2O2 Services
 Proven technology - highly effective, quick to deploy and
utilize, no toxic or harmful by-products.
 Inclusive of all equipment and materials.
 Knowledgeable, flexible staff.
 Committed, long term relationship.
 Turn-key operation.
 24/7 “on-call” availability.
Turn-Key Operation
Site survey.
Functional qualification of each area.
Tailored to customer’s schedule.
Process repeatability and quality control.
Documented process and results.
Record keeping.
24/7 “on-call” availability

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