Slide 1

Report
Epidemiology and Prevention
of Viral Hepatitis A to E:
Hepatitis E Virus
Division of Viral Hepatitis
Geographic Distribution of Hepatitis E
Outbreaks or Confirmed Infection in
> 25% of Sporadic Non-ABC Hepatitis
Hepatitis E –
Epidemiologic Features
• Most outbreaks associated with
fecally contaminated drinking water
• Minimal person-to-person transmission
• U.S. cases usually have history of travel
to HEV-endemic areas
Hepatitis E – Clinical Features
Incubation period:
Case-fatality rate:
Average 40 days
Range 15-60 days
Overall, 1%-3%
Pregnant women,
15%-25%
Illness severity:
Increased with
age
Chronic sequelae:
None identified
Hepatitis E Virus Infection
Typical Serological Course
Symptoms
IgG anti-HEV
ALT
Virus
0
1
2
3
4
in stool
5
6
IgM anti-HEV
7
Weeks after Exposure
8
9
10 11 12 13
Prevention and Control Measures
for Travelers to HEV – Endemic Regions
• Avoid drinking water (and beverages with ice)
of unknown purity, uncooked shellfish, and
uncooked fruit/vegetables not peeled or
prepared by traveler
• IG prepared from donors in Western countries
does not prevent infection
• Unknown efficacy of IG prepared from donors
in endemic areas
• Future vaccine (?)
CDC – Educational and Training
Resources
• Website: www.cdc.gov/hepatitis
•
Toll-free information: 888-4HEPCDC
(888-443-7232)
•
Web-based HCV training for professionals
(http://www.cdc.gov/ncidod/diseases/hepatitis/training/index.htm)
•
Brochures, posters, slide sets, videos
(http://www.cdc.gov/ncidod/diseases/hepatitis/resource/index.htm)

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