Diapositiva 1 - Roma Tre University

Report
Cellular response to DNA damage
Reponse
Mechanisms
Tolerance of DNA damage
Replicative bypass of template damage
Translesion DNA synthesis
Reversal of DNA damage
Enzymatic photoreactivation
Repair of O6-alkylguanine, O4alkyltimidine
Ligation of DNA strand breaks
Excision of DNA damage
Base Excision Repair
Nucleotide Excision Repair
Mismatch Repair
Double strand breaks ligation
Single strand annealing
Recombinational Repair
Non-Homologous End Joining
La radiazione Solare può essere distinta in 3 componenti principali a seconda della
lunghezza d’onda:
ULTRAVIOLETTO (100-400 nanometri)
10%
VISIBILE ( 400-750nm.)
45%
INFRAROSSO (750-3000nm.)
45%
UV-induced damage
UV-responsive photolyases
Direct reversal (de-alkylating proteins)
Base Excision Repair
Nucleotide Excision Repair
(E.coli)
Nucleotide Excision Repair
(Global Genome Repair -Humans)
Nucleotide Excision Repair
(Transcription Coupled -Humans)
Common features of GGR & TCR

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