vesisorb-slide-show - SourceOne Global Partners

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SourceOne Global Partners
“A PARTNERSHIP IN HEALTH & WELLNESS”
Pure Science. Innovative Thinking. Unparalleled Quality
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Presentation Agenda
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Introductions, SourceOne and Vesifact
What is the VESIsorb® delivery system
How it works, the features and benefits
“Seeing is believing”
Providing science-based solutions…
Global market leadership…
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SourceOne Global Partners
“Our Success Insures Your Success”
We provide health and wellness solutions,
created through scientific research and
innovative product development. Our focus
is on clinically proven formulations,
combined with technologically-advanced
and patented delivery systems
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The SourceOne Difference
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SourceOne has distinguished itself as a premier innovator of scientifically
proven health products and technologies.
Our leadership team has forged numerous global partnerships and
alliances resulting in competitive advantages and added value to the
portfolio we bring to the global marketplace.
The synergies created by these partnerships are directly and immediately
applicable to the new products we are introducing and those we are
developing.
The many benefits derived from these innovations and the technology
exchange will resonate with our client partners and ultimately the
consumer focused on health and wellness.
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Exclusive Partnership with
World Leader in advanced delivery systems
Through SourceOne’s exclusive partnership with Vesifact, a
world leader in micro emulsions, nano-colloids, drug delivery,
and other innovative delivery systems, we are a leading
solution provider for dramatically improving absorption and
bioavailability of poorly absorbed ingredients.
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Vesifact Swiss Precision,
Closed Loop Sterile Production Facility
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The latest breakthrough is VESIsorb®
What is VESIsorb®?
A naturally self-assembling colloidal
delivery system that enables us to meet
the growing demand for enhanced
bioavailability of unique science-based
formulas taking their absorption and
efficacy to the next level.
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Self-Assembling Delivery System
• VESIsorb® keeps water insoluble respectively fat soluble
molecules in a hydrophilic environment (e.g. water, gastric
fluids) in solution.
• VESIsorb® does not change a molecule chemically.
• It is a solubilizing vehicle comprising an oil core surrounded by
a monolayer membrane (emulsifiers).
• These emulsifiers link the two surface areas between water and
oil. Without “linking molecules”, it is impossible to get a stable
oil/water mixture (emulsion).
• This is a dynamic process, no static, and it allows the molecules
(emulsifiers, oils, actives) to move perpetually from one droplet
to another or other membranes (e.g. enterocytes).
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VESIsorb®…Three Step Process
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Advantages in Technology
•Non-aqueous lipid-based
composition containing an active
ingredient
•On contact with an aqueous phase
a colloidal delivery system
containing the active ingredients is
spontaneously formed (selfassembling)
•Superior Characteristics of the
colloidal delivery system
• Size <100nm, typically <50nm
• Highly uniform size
distribution
CoQsource®
“H2O”
Colloidal solubilized
active
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Patented All-Natural Delivery System
CoQ10 Colloid Phase
CoQsource®
CoQ10 Pre-Colloid Phase
CoQ10
(Ubiquinone)
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Micelle vs. Liposome vs. Colloidal
Delivery System
Micelle
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Shell: Hydrophilic
surfactant head
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Core: Hydrophobic
surfactant tail
Liposome
• Shell: Bi-Layer
Colloidal
• Shell: Mono-layer
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Core: Water
Core: Oil
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CoQ10 Bio-enhanced formulations
compare absorption data to CoQ10
powders
• 3 studies show peak absorption of CoQ10 powder of
.51, .85 and 2.15 average = 1.17
• 3 studies using soft gels in oily dispersion show peak
absorption…1.32, 1.76 and 1.98 average = 1.69
• 3 studies various delivery systems… 2.24, 3.57, and
4.48 average = 3.43
VESIsorb® colloidal droplet peak absorption… 16.97
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Published Study Results
The graph above provides a vivid illustration of the difference
in CoQsource® (orange line) versus the three other “bioenhanced” CoQ10 products in plasma concentration levels
after one hour, but continues to increase dramatically before
reaching Cmax at about 4 hours. The plasma concentration
of CoQsource® remains well above the levels of the 3 other
treatments throughout the 23 hour period.
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Consistent Clinical Results
CoQ10 Ubiquinone & Ubiquinol-QH
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Consistent PK Results
Omega-3 EPA/DHA
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OmegaChoice® in the VESIsorb® delivery
system turns concentrated Omega-3
EPA/DHA into water soluble colloidal
droplets increasing absorption and
broadening the possible applications.
A pharmacokinetic pilot study comparing
OmegaChoice® 90 Concentrated Omega-3
EPA to the same OmegaChoice™ 90 in the
VESIsorb® delivery system demonstrated an
increase of 567% in peak blood levels (cmax)
of EPA.
The relative bioavailability calculated using
the area under the curve (AUC 01-12h) was
also increase by 487%.
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Delivers Maximum Benefits
• Consistent advantage of optimal
performance under all conditions
• Absorption & bioavailability impacted by
– Aging population = nutrient absorption declines
with age
– Low-Fat Diet…see Omthera study Lovaza vs.
Epanova
– Sickness & Stress negatively impact absorption
– More standard capsules = < efficient absorption
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COMPETING CoQ10 PRODUCT
OIL DROPS SITTING ON WATER
DOES NOT GO
INTO SOLUTION
SEPARATION OF COMPONENTS
(NO EMULSIFICATION)
COLLOIDAL DROPLET FORMATION
100% IN SOLUTION!
COMPLETELY HOMOGENOUS
COLLOIDAL SOLUTION!
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STANDARD TG OMEGA-3 PRODUCT
OIL DROPS
SITTING ON WATER
DOES NOT GO
INTO SOLUTION
SEPARATION OF COMPONENTS
(NO EMULSIFICATION)
COLLOIDAL DROPLET
FORMATION
100% IN SOLUTION!
COMPLETELY HOMOGENOUS
COLLOIDAL SOLUTION!
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Leading CoQ10 and QH Ubiquinol
Supplement Brands
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SourceOne TocoSource® vs.
Patented Competitive Tocotrienols
Homogeneous Delivery System
• Homogenous versus
Heterogeneous
• Speed of conversion
• Stability
• Reproducibility for
consistency at the
consumer level
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VESIsorb® Fluid Droplets - Cryo
Electron Micrograph
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Vesifact Intellectual Property (IP)
and Know How
VESIFACT HOLDS OVER 40 INTERNATIONAL
PATENTS AND PATENTS-PENDING IN OVER
20 COUNTRIES
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The following listing is an overview of key U.S and European VESIsorb® oral and topical
patents for both pharmaceutical and nutraceutical formulations. Additionally we have
patents and patents pending in Japan, China, Hong Kong, Korea, Singapore, Brazil,
India, Indonesia, Mexico, Philippines, Russia, Thailand, Taiwan and Argentina.
Vesifact Patents & Patent Applications:
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Europe patent 1,249,502…”Microemulsion-preconcentrates, microemulsions and use of such a
composition”
Europe patent 1,249,230…”Microemulsion-preconcentrates, microemulsions comprising coenzyme Q10”
for oral and topical application
Europe patent 852,941…”Nanodispersion cosmetic composition” for topical applications ; any cosmetic
active is a candidate
U.S. patent 5,997,888…”Cosmetic preparations” for improved absorption in topical applications; any
cosmetic active is a candidate
Europe patent 1,249,231…”Pharmaceutical formulations containing anti-inflammatory active ingredients
and the use of said formulations”
Europe patent 956,851…”Use of nanodispersions in cosmetic end formulations” for improved absorption
in topical applications; any cosmetic active is a candidate
U.S. patent 7,008,638…”Use of nanodispersions in cosmetic end formulations”
Europe patent 956,853…”Use of nanodispersions in pharmaceutical end formulations for oral and topical
applications of any pharmaceutical ingredients”
U.S. patent 7,081,253…”Use of nanodispersions in pharmaceutical end formulations for oral and topical
applications of any pharmaceutical ingredients”
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What Do Consumers Want?
•To take fewer capsules
•To take smaller capsules
•To receive the maximum benefits
from their supplements
•Greater bioavailability & absorption
…With
is more!
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The VESIsorb® Solution
Size Matters
With VESIsorb®, you need less to achieve more. Fewer soft
gels in your daily regimen to achieve better results.
=
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• VESIsorb® technology has a green
impact on the environment.
• The efficient use of resources results in
fewer bottles, less packaging waste and
reduced transportation needs.
• By increasing bioactive absorption, like
CoQ10, this in turn reduces the number
of soft gels needed per day to achieve
blood plasma levels for optimum health
and wellness.
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Patented, clinically proven
formulations in leading brands
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Advanced Innovative technologies
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Summary
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