Bio-Xplore Final Conference December 4th, 2014 Hadassah Academic College Jerusalem Israel BIO-XPLORE MISSION Utilize financial and human resources to discover, develop and commercialize health and wellness products derived from Mediterranean plants Promote human health based on scientific knowledge Impact academic education Stimulate regional economic development and communication Create an active collaboration among partners Bio-Xplore Vision Contribute to regional economic development and social well being Making Bio-Xplore Partnership the conduit for bringing people together from different cultures, religions and regions Using science to communicate and create trust THE MAIN OBJECTIVES Establish a strong and integrative working team based on mutual trust and complementary skills and resources Train people in all partners areas in the screening and discovery of plant derived bioactives Develop new screening assays according to the directions of the Global Institute of Bio Exploration (GIBEX) WEB SITE New screens developed 1. 2. 3. 4. Anti viral assay Anti cancer assay Acethylcholine esterase inhibition assay Modified Glucosidase and Glucosidase inhibition assay 5. Anti cellulite assay: Phosphodiesterase inhibitor Peer-reviewed publications Gili Joseph, Mina Faran, Ilya Raskin, Mary Ann Lila and Bertold Fridlender Medicinal Plants of Israel: A Model Approach to Enable an Efficient, Extensive, and Comprehensive Field Survey.. J Biodivers Biopros Dev 2014, 1:3 Sigal Matza-Porges, Kobi Eisen, Hadeel Ibrahim, Adva Haberman,Bertold Fridlender,Gili Joseph. A new antiviral screening method that simultaneously detects viralreplication, cell viability, and cell toxicity. Journal of Virological Methods 208 (2014) 138–143 Ibrahim M. Abu-Reidah, Mohammed S. Ali-Shtayeh , Rana M. Jamous David Arrבez-Romבn, Antonio SeguraCarretero HPLC–DAD–ESI-MS/MS screening of bioactive components from Rhus coriaria L. (Sumac) fruits Food Chemistry 166 (2015) 179–191 Ahmad Ibrahim HuseinMohammed Saleem Ali-Shtayeh, Waheed Jebril Jondi, Nidal Abd-Aljapar Zatar, Ibrahim M. Abu-Reidah, and Rana M. Jamous. In vitro antioxidant and antitumor activities of six selected plants used in the Traditional Arabic Palestinian herbal medicine. Pharm Biol, Early ( 2014): 1–7 Mohammed Saleem Ali-Shtayeh1 Rana Majed Jamous1, Salam Yousef Abu Zaitoun1, and Iman Basem Qasem1 Invitro screening of acetylcholinesterase inhibitory activity of extracts from Palestinian indigenous flora in relation to the treatment of Alzheimer’s disease. Functional Foods in Health and Disease 2014; 4(9):381-400 Peer-reviewed publications Abu- Reidah, I. M., Jamous, R.M., Ali-Shtayeh, M. S., (2014) Phytochemistry, pharmacological properties and Industrial application of Rhus coriaria l. ( Sumac): A review. Jordan Journal of Biological Sciences (JJBS). 12/2014; 7(4):233 - 244. Husein, A.I., Ali-Shtayeh, M. S., Jamous, R.M., Abu Zaitun, S.Y., Jondi, W.I., Zatar, N.,(2014) antimicrobial activities of six plants used in traditional Arabic Palestinian Herbal medicine. African Journal of Microbiology Research 01/2014; 8(38):3501-3507. Husein, A.I., Ali-Shtayeh, M. S., Jamous, R.M., Jondi, W.I., Zatar, N.,(2014). Phthalate derivatives are naturally occurring in Arum palaestinum. International Journal of Current Research and Academic Review. 01/2014; 2(9):195203. Ali-Shtayeh, M. S., Jamous, R.M., Abu-Zeitun S.Y.,(2014). Berc 2014 “National 2014 “ National list of Medicinal plants in Palestine-west Bank and Gaza Strip”. 01/2014; Biodiversity and Evironmental Research Center What was done in the Bio-Xplore project All partners sampled and extracted 1000 samples or more. All partners performed all 10 assays on all samples. All partners continued the screening by using the dose response method for the samples that scored the highest activity ( score 3). 3 partners (Leitat, BERC and Hadassah) developed new screens. 9 manuscripts were published in peer reviewed journals 2 articles were published in Israeli journals (in Hebrew) and 1 article in Spain (in Spanish). What are we delivering!!! Identification of plants with commercial potential Increased employment and business opportunity in the agriculture, food, cosmetics and biotech industry Cross Border interaction among partners Increased awareness of the local public population to the value of their natural flora Improved scientific and industrial knowledge of the institutions involved Thank you for being here!