System description

Report
Cecumo
Cell-Culture real time Monitoring system
Analog Design Contest 2013
Team: José A. Maldonado, Juan N. Olmo, Gloria Huertas, Alberto Yúfera
“The important thing is not to stop questioning”. Albert Einstein
AGENDA
Motivation
 Theoretical background



Simulations
System description
Implementation
 Features
 Results

Final conclusions
 Questions and comments

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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
MOTIVATION
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
THEORETICAL BACKGROUND
Z(w)/A
CELL
Rs
Z(w)/(A-Ac)
Rs
Z(w)/Ac Rgap
Low-Pass Behaviour
function of cell-culture
occupation area (Ac)
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
THEORETICAL BACKGROUND: SIMULATIONS
Zcell-electrode(s)
Vout2
Rin
Vout
HBP(s)
Oscillation-Based Test approach
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: RESULTS
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: RESULTS
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: FEATURES
Real time monitoring
 “Cell friendly” (Max. 30mV/30μA)
 Immediate result
 Up to 8 cultures
 Wireless connectivity
 Data logging
 Long battery lifetime (100mA/10mA@±5V)
 Compact and light-weight design (160x80x25mm)

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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
CONCLUSIONS
Low cost & reusable “biological” oscillator for Cell
Culture growing measurements.
 Amplitude and frequency to characterize occupation.
 AGC for better noise inmunity
 Frequency and AGC control voltage (Vg) to extract Fill
Factor (ff) parameter.
 Potential fields of application: medicine and biology
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
QUESTIONS AND COMMENTS
Thank you for your attention!
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION

Band Pass Filter
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION

AGC
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION

BioZ Interface
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo
SYSTEM DESCRIPTION: IMPLEMENTATION

High Pass Filter & Comparator
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Analog Design Contest 2013
José A. Maldonado, Juan N. Olmo

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