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Multi-Compartment Pharmacokinetics Chapters 19 and 20 http://www.boomer.org/c/p4/ One versus Two Compartment • Rapid Equilibrium versus Slower Equilibrium http://www.boomer.org/c/p4/c19/c1901.html Multi-Compartment Pharmacokinetic Model • • • • • • • • Deviation from One Compartment Model Models and Parameters Equations Parameter Estimation Effect of Changing Parameters Apparent Volumes of Distribution Dosage Calculations Oral Administration Multi-Compartment Pharmacokinetic Model This Equation is A. The integrated equation for concentration after an IV bolus B. The differential equation for concentration after an IV bolus C. The integrated equation for concentration after an oral dose A Two Compartment Model becomes One when A. k12 and k21 are fast B. k21 is faster than k12 C. CLD is fast D. All of the above Varea is Calculated using A. The dose and the intercept values (A and B) B. The dose, AUC and beta C. V1 and the microconstants Achieving and maintaining a specified Cp is easier with a 2C drug A. True B. False Non Compartmental Analysis • • • • Linear (First-order) Kinetics No Model ‘Requirement’ New Parameters – AUMC, MRT, MAT Faster Calculation with Spreadsheet or SAS Non Compartmental Analysis The mean residence time can be calculated as A. B. C. D. AUMC/AUC AUC/AUMC AUMC2 Dose/AUC An estimate of ka can be calculated from A. B. C. D. AUC AUMC MRT MAT Do you usually have your laptop AND phone connected to WiFi in this room? A. True B. False Have you had problems connecting to the WiFi in this room? A. Never B. Occasionally C. Often Have you had problems connecting to the WiFi in this room during in-class Quiz or Exams A. True B. False