52 陳黎68 曾資斌

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Emotional Memory
( The Prefrontal Cortex)
&
Phineas Gage
B9902052 陳 黎
B9902068 曾資斌
A Gruesome but True Story
Phineas P. Gage (1823 –1860)
 construction foreman
 left frontal lobe destroyed
 effects ?


"no longer Gage".
生理機能正常
左前額葉與生
理機能無關
情緒表現異常
左前額葉與情
緒表現相關
左前額葉皮
質嚴重損壞
How?

Before & After
The Limbic System
Take a Closer Look……
Before
 After
 Why?? Prefrontal cortex damaged

Emotionally
detached
impatient
erratic
The Lymbic System
Prefrontal cortex(PFC)

Frontal lobe
granular
 electrical stimulation

evoke movements
Motor cortex
Premotor area
Prefrontal cortex
Function

Importance?

CEO of the brain
Jiminy cricket
“It is the tiny voice help you decide what is right
and wrong.”

When PFC goes wrong…


運作過度……
活動低落……
(lack of dopamine)
What happened to Gage?
•
•
Destroyed
Not destroyed
PFC & ADHD

意力不足過動障礙症(過動症)

Attention Deficit Hyperactivity Disorder
Why?
 Dopamine
 dopa decarboxylase

多巴脫羧酵素
Lobotomy 前額葉切離手術

Egas Moniz, 1935

Schizophrenia, clinical depression

Connections to PFC
Reference

PHINEAS GAGE :A Gruesome but True Story About Brain Science,
by John Fleischman, 2002

Making A Good Brain Great, by Daniel G. Amen, 2007

認識你的頭腦, 洪祖培教授、邱浩彰醫師著

http://en.wikipedia.org/wiki/Prefrontal_cortex

http://en.wikipedia.org/wiki/Lobotomy

http://www.dls.ym.edu.tw/neuroscience/adhd_c.html

http://sanitaryplaza.blogspot.com/2007/07/lobotomy.html

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