FDG Synthesizers

Report
Radiopharmaceutical
Production
FDG Synthesizers
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Introduction
This module provides basic
information on FDG production
chemistry. These links will lead you
to presentations about the synthesis
of FDG in general, how the
commercial synthesizers work and
some common problems with FDG
synthesis. The next slide gives an
overview of the commercially
available synthesizers.
Content
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Overview of FDG synthesis.
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How Synthesizers work
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Troubleshooting Guide for
FDG Synthesis
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Commercial Synthesizers
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Introduction
This module provides an overview of
the commercially available FDG
synthesis units.
In all cases, please follow the links
to the company website to get the
latest information on each
synthesizer
Content
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ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
ACSI
Radiopharmaceutical
Production
FDG Synthesis Units
Content
ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
STOP
WEB PAGE ACSI
The Advanced FDG Carousel Dual Synthesis module is a fully
automated, single-purpose device that produces sterile, pyrogenfree Fluoro-Deoxy-Glucose (FDG) suitable for human use. The
only user intervention required is loading of the starting kits, and
removal of the final product. A Lookout based user interface
keeps the user informed of the status of the production.
The sequence and length
of each process step can
be changed easily by
editing an Excel
spreadsheet.
Bioscan FDG-Plus Synthesizer
Radiopharmaceutical
Production
WEB PAGE BIOSCAN

Lower capital costs compared to
other systems
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Lower run costs compared to
other systems
GE HEALTHCARE

Increased reliability
IBA Molecular

True "infinite run" capability on a
single box

Extremely small size - two units
will fit into a single mini hotcell

Improved diagnostics

Improved self-testing

Based on Bioscan’s years of
experience in demanding
commercial FDG labs
FDG Synthesis Units
Content
ACSI
BIOSCAN
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
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GE Healthcare FDG Modules
Radiopharmaceutical
Production
FDG Synthesis Units
WEB PAGE GE HEALTHCARE
Synthesizer Fact sheet
Synthesizer Fact sheet
Content
ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
FASTlab™, a automated PET
radiochemistry synthesis
platform for FDG. FASTlab
offers the versatility and
flexibility to develop and produce
additional fluoride-based tracers
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TRACERlab™ offers a complete
series of synthesizers for small to
medium scale production of PET
tracers, addressing both clinical
and research needs.
IBA Molecular Products |
Synthera
Radiopharmaceutical
Production
WEB PAGE IBA Molecular
FDG Synthesis Units
Content
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ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
STOP
Synthera® is designed to accommodate a wide range of
radiochemistries. Modules can be interconnected in series to
implement complex processes. Creation of different tracers only
requires changing the IFP™ model. Syntheses are
reproduceable.
Integrated Fluidic
Processor (IFP™) is an
innovative solution
for the automation of a
multitude of predefined
syntheses
while offering the benefit
of a disposable system.
Kirams
Radiopharmaceutical
Production
FDG Synthesis Units
Content
ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
STOP
WEB PAGE KIRAMS
KIRAMS
215-4, Gomgneung-Dong, Nowon-Gu, Seoul, 139-706, Korea
Tel : 82-2-970-1331 Fax : 82-2-970-1332
Well established technology
can guarantee high yield and
reproducibility.
Easy maintenance due to
enough rear access.
Customizable software can
make:
•Flexible synthesis.
•Easy application.
•Data tracking is possible in
real-time.
•Automatic graphical reporting
of collected data
Raytest
Radiopharmaceutical
Production
FDG Synthesis Units
Content
ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
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WEB PAGE Raytest
very compact
fully visible process
ultra fast reactor heating /
cooling
magnetic stirrer mixing system
tube lifting system
cartridge product purification
built-in vacuum pump
built-in pressure control
on-line process control
interactive process diagram
fully automatic operation
reported manual intervention
online/offline process
development interface
GLP / GMP / 21CFR part 11
compliant
highest reliability
highest yield ( >55%)
acid or base hydrolysis
possible
Siemens
Radiopharmaceutical
Production
WEB PAGE SIEMENS
FDG Synthesis Units
Content
ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
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Typical System Performance
Yield of synthesis (decay corrected to
EOB) > 65%
Set-up time < 20 minutes
Synthesis time ≤ 45 minutes
Clean up time < 35 minutes
Dimensions
Width 24 in (61 cm)
Depth 14 in (36 cm)
Height 19 in (48 cm)
Weight 150 lbs (68 kg)
Explora is registered trademark of
Siemens Medical Solutions USA, Inc.
See a Powerpoint
presentation about the
Siemens Synthesizers
Sumitomo
Radiopharmaceutical
Production
WEB PAGE SUMITOMO
FDG Synthesis Units
Content
ACSI
BIOSCAN
GE HEALTHCARE
IBA Molecular
KIRAMS
RAYTEST
SIEMENS
SUMITOMO
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Our 18FDG system is
systematized from
synthesis module and
official approval qualityinspection module and
administration dosage
module in the lead
cover,for radiation
exposure reduction
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