Role of fibroblast growth factor receptors in

Report
PASTEUR INSTITUTE SEMINAR SERIES
BIOLOGIA MOLECOLARE
Giovedì 17 novembre, ore 16:00
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presso l'Aula Magna - Viale Regina Elena 295
G
DEGLI EUCARIOTI
Prof. Maria Rosaria Torrisi
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Dept. of Clinical and Molecular Medicine
DI INTERESSE B
Sapienza Università
Istituto Pasteur Italia
BIOL
Role of fibroblast growth factor
receptors in epithelial
homeostasis and carcinogenesis
Signaling of fibroblast growth factors (FGFs), triggered by binding to their
tyrosine kinase receptors (FGFR1-4), is tightly controlled in paracrine and
context-dependent manner andGDEGLI
is crucial
for the epithelial-stromal interaction
EUCARIOTI
and homeostasis. FGF/FGFR signaling is known to play oncogenic roles in
M
tumorigenesis: however, through
the triggering of cell differentiation,
DI INTERESSE B
receptor activation might lead
to opposite tumour suppressive outcome.
Moreover, ligand binding specificity is regulated by alternative splicing and
the switching from FGFRb epithelial to FGFRc mesenchymal isoforms
appears to be involved in cancer progression. Our recent results on the impact
of FGFR2b/2c switch in dysregulating receptor signaling and on the
functional crosstalk among the receptor and the E5 oncogenic viral protein of
the human papillomavirus 16 (HPV16) will be presented and discussed.
per informazioni: [email protected]

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