K-ADNI

Report
KOREAN ADNI
… WHERE ARE WE NOW
Seol-Heui Han, MD, PhD.
On behalf of
Preparatory Committee for K-ADNI
Clinical Research Center for Dementia
of South Korea (CREDOS)
2005
2006
2007
2008
2009
2010
2011
2012
2013
2014
9yr Project
700,000 US dollars /yr
Funded by the Ministry of Health, Welfare, and Family Affairs
Primary focus of CREDOS
Healthy, SMI
aMCI
Cognition
AD
svMCI
SVaD
Time
CREDOS
CREDOS protocols
Items for history
Neuropsychological tests
Cognition
ADL
Behaviors
Differential diagnoses
Scales or questionnaires
Korean Dementia Screening
Questionnaire (K-DSQ)
Barthel- index
Instrumental ADL (Seoul IADL)
NPI
MMSE
CDR
GDS
Hachinski ischemic scale
Geriatric depression scale
Lab
Vitamin B12
Folate
VDRL
TSH/free T4
MRI
Axial T2, T1, FLAIR, (GRE)
Coronal T1
CREDOS D-Matrix
Healthy, SMI
WMH on MRI
minimal
moderate
severe
No cognitive impairment
I-1
I-2
I-3
Mild cognitive impairment
II-1
II-2
II-3
Mild to moderate dementia
III-1
III-2
III-3
Severe dementia
IV-1
IV-2
IV-3
aMCI, AD
svMCI, SIVD
C
O
G
N
I
T
I
O
N
DESIGNING K-ADNI
K-ADNI: Organization Tree
CREDOS
PI:DL Na
Advisory
board ADNI:
M. Weiner
K-ADNI
PI: SH Han
Assistant administrator:
SY Kim , DW Yang
Clinical
Core
Biological
Core
Stroke risk
ADAS-Cog, CDR
ADL,NPI, FBI
Neurologic scale
CSF tau, amyloid
Apo E, GWAS
Lipid, homocysteine,
TFT
Imaging
Core
MRI-VBM, DTI, fMRI
FDG-PET, PIB-PET
Biostatistics
Core
Main aim: Effects of SVD on Progression of AD
Cognition
Time
Plan: 500 cases
WMH on MRI
Cognition
mild
moderate
severe
No cognitive impairment
100
0
0
Mild cognitive impairment
100
50
50
Mild to moderate dementia
100
50
50
0
0
0
Severe dementia
K-ADNI
5yr Longitudinal study
2010
2011
Recruitment
N=500
NPT
Biomarker
Imaging
NPT
Biomarker
Imaging
2012
2013
2014
2015
Follow up
NPT
Biomarker
Imaging
NPT
Biomarker
Imaging
Neuropsychological Tests
SNSB, ADL,CGA-NPI, FBI
Biomarker
Blood: Apo E polymorphism, Genome-wide study
CSF
Imaging studies
MRI
PET: FDG-PET, PIB-PET
NPT
Biomarker
Imaging
NPT
Biomarker
Imaging
Ready to go
 Funding sources ($1.5 M/yr for
5 years)
 Government
 Private donations
 Industry support

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